非编码RNA调控胰腺纤维化研究进展  

Research progress in the role of non-coding RNA in regulating pancreatic fibrosis

作　　者：翟航 张广权 吴芳芳 史宪杰 Zhai Hang;Zhang Guangquan;Wu Fangfang;Shi Xianjie(Department of Hepatobiliary and Pancreatic Surgery,the Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518033,China)

机构地区：[1]中山大学附属第八医院肝胆胰外科,深圳市518033

出　　处：《中华肝脏外科手术学电子杂志》2024年第4期583-587,共5页Chinese Journal of Hepatic Surgery(Electronic Edition)

基　　金：深圳市科创委基础研究项目(面上项目)(JCYJ20220530144404010,JCYJ20220530144404011)

摘　　要：胰腺纤维化(PF)是各种致病因子导致的胰腺组织损伤修复的病理过程,其病理特点主要为反复发作的炎症、坏死引起的细胞外基质(ECM)成分在胰腺内的过度沉积,胰腺纤维化的发生发展与慢性胰腺炎、胰腺癌和胰腺囊性纤维化等疾病密切相关。胰腺星状细胞(PSCs)的活化、合成和分泌大量细胞外基质成分是贯穿胰腺纤维化的核心事件。近年研究表明,非编码RNA(ncRNA)在胰腺纤维化发生发展中发挥重要作用。明确ncRNA在胰腺纤维化发生过程中的作用机制,有助于丰富胰腺纤维化作用机理,并为其治疗提供依据。因此,本文对ncRNA在胰腺纤维化的作用机制进行了阐述。Pancreatic fibrosis(PF)is a pathological process of pancreatic tissue damage and repair caused by multiple pathogenic factors.The pathological characteristics mainly include excessive deposition of extracellular matrix(ECM)components in the pancreas caused by recurrent inflammation and necrosis.The incidence and development of PF are intimately associated with multiple diseases such as chronic pancreatitis,pancreatic cancer and pancreatic cystic fibrosis,etc.The activation,synthesis and secretion of a large quantity of ECM components by pancreatic stellate cells(PSCs)are the core events throughout the process of PF.Recent studies have shown that non-coding RNA(ncRNA)plays an important role in the development of PF.Clarifying the mechanism of ncRNA in the process of PF contributes to unraveling the mechanism of PF and providing basis for rational treatment.Therefore,the mechanism underlying the role of ncRNA in PF was illustrated.

关 键 词：胰腺纤维化 胰腺星状细胞 非编码RNA 

分 类 号：R576[医药卫生—消化系统]