胰腺神经内分泌肿瘤转化治疗进展  

Progress in transformation therapy for pancreatic neuroendocrine neoplasms

作　　者：邓小巍 邵成浩 Deng Xiaowei;Shao Chenghao(Department of Pancreatic-biliary Surgery,Changzheng Hospital of Naval Military Medical University,Shanghai 200003,China)

机构地区：[1]上海市海军军医大学附属长征医院胰胆外科,200003

出　　处：《中华肝脏外科手术学电子杂志》2024年第4期456-460,共5页Chinese Journal of Hepatic Surgery(Electronic Edition)

摘　　要：神经内分泌肿瘤(NENs)是异质性肿瘤,起源于胃肠胰的神经内分泌肿瘤可细分为高分化的神经内分泌肿瘤和神经内分泌癌,其中高分化的神经内分泌肿瘤可以根据Ki-67指数细分为NET G1、G2和NET G3,根据其是否有激素分泌功能分为功能性以及非功能性肿瘤,其中大部分为非功能性肿瘤,所以通常起病隐匿,很多患者发现时已存在局部进展和(或)远处转移,转化治疗对于晚期神经内分泌肿瘤患者具有重要意义。本文根据晚期肿瘤不同的生物学行为,总结目前常用的转化治疗方法。根据不同肿瘤的特点,合理设计患者的治疗方式,必要时进行药物联合治疗达到精准化、个性化治疗。Neuroendocrine neoplasms(NENs)are heterogeneous neoplasms.NENs arising from the stomach,bowel and pancreas can be divided into high-differentiated neuroendocrine tumors(NET)and neuroendocrine carcinoma,among which high-differentiated NET can be subdivided into NET G1,G2 and NET G3 according to Ki-67 index,and classified into functional NET and non-functional NET according to the function of hormone secretion.NF-NET is the dominant type,manifested with elusive onset.Many patients have local progression and/or distant metastasis upon diagnosis.Transformation therapy is of significance for patients with advanced NET.In this article,common transformation therapies were summarized based on different biological behaviors of advanced tumors.According to the characteristics of different types of tumors,appropriate treatment approaches were determined.Drug combination therapy should be carried out to achieve precise and individualized treatment when necessary.

关 键 词：神经内分泌肿瘤 神经内分泌癌 转化治疗 术前治疗 

分 类 号：R735.9[医药卫生—肿瘤]