肌少性肥胖与非酒精性脂肪性肝病间的关系以及研究进展  

Research progress and the relationship between nonalcoholic fatty liver disease and sarcopenic obesity

作　　者：张杨杨 项楚淇 朱满生 Zhang Yangyang;Xiang Chuqi;Zhu Mansheng(School of Stomatology,Stomatological Hospital,Southern Medical University,Guangzhou 510515,China;the First College of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;Guangdong Provincial Key Laboratory of Presicion Medicine for Gastrointestinal Tumor,Department of general surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学口腔医学院,广州510515 [2]南方医科大学第一临床医学院,广州510515 [3]南方医科大学南方医院普通外科·广东省胃肠肿瘤精准微创诊疗重点实验室,广州510515

出　　处：《中华肥胖与代谢病电子杂志》2024年第4期276-282,共7页Chinese Journal Of Obesity and Metabolic Diseases:Electronic Edition

基　　金：国家自然科学基金项目(82103150);广东省胃肠肿瘤精准微创诊疗重点实验室(2020B121201004);广州地区临床重大技术项目(2023P-ZD01)

摘　　要：非酒精性脂肪性肝病(NAFLD)是内脏脂肪过度堆积的重要表现之一,也是导致终末期肝硬化和肝细胞癌的重要原因。部分NAFLD患者合并肌少性肥胖(SO),尤其是老年患者。随着老龄化加剧,SO作为肥胖症的特殊类型而备受关注。从病理生理学角度看,SO与NAFLD有多种共同影响因素,如炎症、衰老、胰岛素抵抗、肌因子等。然而,其中的相互作用关系尚不清晰。减重代谢手术是改善机体糖脂代谢的有效手段,也能使老年肥胖患者获益。明确SO的发病机制及其代谢紊乱过程,是评估减重代谢手术在治疗SO可行性的重要前提。本文就SO和NAFLD的发病机制来分析SO和NAFLD间的相互关系,并初步介绍相关的治疗进展。Non-alcoholic fatty liver disease(NAFLD)is a pathologic condition manifested by the excessive accumulation of visceral fat in the liver so much so that it gradually progresses to end-stage liver cirrhosis and hepatocellular carcinoma.Some of the NAFLD patients could be comorbid with sarcopenic obesity(SO),especially those of the elderly.As the world's aging population grows,SO has come into the spotlight as a special type of obesity.From the perspective of pathophysiology,SO and NAFLD share many common influencing factors,such as inflammation,aging,insulin resistance,myokines,etc.However,the interactions between these factors remain elusive.Bariatric metabolic surgery has been an effective means to improve glucose and lipid metabolism for young adults and older patients with obesity as well.Clarifying the pathogenesis of sarcopenic obesity and the mechanism of the metabolic disorder process is an important prerequisite for evaluating the feasibility of bariatric and metabolic surgery.In this review,we tried to elucidate the pathogenesis and interrelationship of sarcopenic obesity and NAFLD and provide an overview of the related treatment advancements.

关 键 词：非酒精性脂肪性肝病 肌少性肥胖 衰老 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]