MAPK信号通路相关非编码RNA在胶质瘤中的研究进展  

Recent findings on MAPK signaling pathway and non-coding RNA in glioma

作　　者：陈诚 陈保东 Cheng Chen;Baodong Chen(Department of Neurosurgery,Peking University Shenzhen Hospital,Shenzhen 518000,China)

机构地区：[1]北京大学深圳医院神经外科,深圳518000

出　　处：《中华神经创伤外科电子杂志》2024年第6期376-381,共6页Chinese Journal Of Neurotraumatic Surgery:Electronic Edition

摘　　要：脑胶质瘤是成人中枢神经系统发病率最高的原发恶性肿瘤,发病率约占所有中枢神经系统原发恶性肿瘤的50.1%。非编码RNA(ncRNA)是一类能转录但不编码蛋白质的RNA分子,广泛存在于真核生物基因组中,已被证明参与多种疾病生物过程,如细胞增殖、凋亡、迁移和侵袭等。研究表明微小RNA、长链ncRNA和环状RNA等ncRNA可通过多条信号转导通路参与调节胶质瘤的生物学行为及进展,而MAPK信号通路相关的ncRNA是胶质瘤诊断、预后评估和治疗的潜在生物标志物。基于此,本文围绕MAPK信号通路相关的ncRNA在胶质瘤发生发展中的作用及临床应用展开综述,旨在为胶质瘤的治疗寻找新的潜在生物标志物。Glioma is the primary malignant tumor with the highest incidence rate in the adult central nervous system,and the incidence rate is about 50.1%.Non coding RNA(ncRNA)is a type of RNA molecule that can transcribe but does not encode proteins.It is widely present in eukaryotic genomes and has been shown to participate in various disease biological processes,such as cell proliferation,apoptosis,migration,and invasion.Research has shown that ncRNA such as microRNA,long nRNA,and circular RNA can participate in regulating the biological behavior and progression of gliomas through multiple signaling pathways,and ncRNAs related to the MAPK signaling pathway are potential biomarkers for glioma diagnosis,prognosis evaluation,and treatment.Therefore,this article reviews the role and clinical application of ncRNA related to the MAPK signaling pathway in the occurrence and development of gliomas,aiming to explore new potential biomarkers for the treatment of gliomas.

关 键 词：胶质瘤 非编码RNA MAPK信号传导途径 

分 类 号：R739.41[医药卫生—肿瘤]