慢性肝病肝纤维化无创诊断的研究进展  

Progress in noninvasive diagnosis of liver fibrosis in chronic liver disease

作　　者：李浩 陈棋帅 费发珠 张宁伟 李元东 王硕晨 任宾[1] Li Hao;Chen Qishuai;Fei Fazhu;Zhang Ningwei;Li Yuandong;Wang Shuochen;Ren Bin(Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hospital of Qinghai University,Xining 810012,China;Department of Oncology Surgery,Affiliated Hospital of Qinghai University,Xining 810012,China)

机构地区：[1]青海大学附属医院肝胆胰外科,青海西宁810012 [2]青海大学附属医院肿瘤外科,青海西宁810012

出　　处：《中华临床医师杂志(电子版)》2024年第9期863-867,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：2021年度青海省“昆仑英才·高端创新创业人才”项目

摘　　要：慢性肝病可由多种因素引起,如病毒性、酒精、非酒精性脂肪性肝病、自身免疫性、药物性肝损伤和遗传因素等。肝维化是各种慢性肝病的一种重要病理性修复反应,与肝脏肿瘤和死亡密切相关。尽管肝组织活检是诊断肝纤维化的金标准,但有创且局限。当前的组织病理学纤维化分期系统对纤维化监测不够敏感。因此,对肝纤维化进行早期和无创的诊断以及准确的分期,是治疗和控制肝纤维化进展的关键。文章综述了慢性肝病患者肝纤维化无创性诊断方法的研究进展。Chronic liver disease can be caused by a variety of factors,such as viral disease,alcohol and non-alcoholic fatty liver disease,autoimmune disorder,drug-induced liver injury,and genetic factors.Liver fibrosis is an important pathological repair reaction to various chronic liver diseases,which is closely related to the development of liver tumors and death.Although liver biopsy is the gold standard for the diagnosis of liver fibrosis,it is invasive and has limited use.The current histopathological fibrosis staging system is not sensitive enough to fibrosis monitoring.Therefore,early and non-invasive diagnosis and accurate staging of liver fibrosis are the key to treating and controlling the progression of fibrosis.This article reviews the progress in research of non-invasive diagnostic methods for liver fibrosis in patients with chronic liver disease.

关 键 词：肝纤维化 慢性肝病 无创诊断 

分 类 号：R575[医药卫生—消化系统]