乳腺癌肿瘤内微生物组的研究进展  

Advances in research of intratumoral microbiome in breast cancer

作　　者：刘琦 王守凯 王帅 苏雨晴 马壮 陈海军[2] 司丕蕾 Liu Qi;Wang Shoukai;Wang Shuai;Su Yuqing;Ma Zhuang;Chen Haijun;Si Pilei(Department of Breast Surgery,Zhengzhou University People's Hospital,Zhengzhou 450003,China;Department of Breast Surgery,Henan Provincial People's Hospital,Zhengzhou 450003,China;Henan Provincial Engineering Research Center of Breast Cancer Precise Prevention and Treatment,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院乳腺外科,郑州450003 [2]河南省人民医院乳腺外科,郑州450003 [3]河南省乳腺癌精准防治工程技术研究中心,郑州450003

出　　处：《中华临床医师杂志(电子版)》2024年第9期841-845,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然基金资助项目(82102937);河南省卫生健康委员会项目(YXKC2021026,SBGJ202402015)

摘　　要：肿瘤内微生物组是指存在于肿瘤中并构成肿瘤微环境的微生物群体。随着宏基因组学技术的进步,人们对肿瘤内微生物群体的组成和功能有了更深入的了解,而日益增多的证据表明细菌等微生物确实能够存活于包括乳腺癌在内的多种肿瘤组织中并与肿瘤的发生、发展及耐药有一定的相关性。本文综述了与乳腺癌发生、进展和复发转移相关的肿瘤内微生物及其作用机制,并展望了其未来通过干预肿瘤微生态实现乳腺癌精准治疗的临床应用前景。The intratumoral microbiome refers to the microbial community residing within tumors,forming a crucial part of the tumor microenvironment.With advancements in metagenomic technologies,there has been a deeper understanding of the composition and functions of these microbial communities.Growing evidence suggests that microorganisms,such as bacteria,can indeed survive within various tumor tissues,including breast cancer,and are associated with tumorigenesis,disease progression,and drug resistance.This review summarizes the intratumoral microbiota related to the initiation,progression,and recurrence of breast cancer,elucidating their mechanisms of action.Additionally,this paper also explores the potential clinical applications of targeting the tumor micro-ecosystem for precision treatment of breast cancer.

关 键 词：乳腺癌 肿瘤内微生物群 发病机制 研究进展 

分 类 号：R737.9[医药卫生—肿瘤]