依达拉奉右莰醇治疗急性缺血性卒中的疗效及对患者血清Trx、NLR水平的影响  

Effect of edaravone dexborneol treatment on Trx,NLR and neurological function in patients with acute ischemic stroke

作　　者：王益 许璐 Yi Wang;Lu Xu(Department of Neurology,Jiangsu University Affiliated Hospital of Jurong(the People's Hospital of Jurong),Zhenjiang 212400,China)

机构地区：[1]江苏大学附属句容医院(句容市人民医院)神经内科,镇江212400

出　　处：《中华脑科疾病与康复杂志(电子版)》2024年第6期359-364,共6页Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition)

基　　金：镇江市社会发展指导性项目(FZ2023032);句容市社会发展科技计划项目(ZA42208)

摘　　要：目的探讨依达拉奉右莰醇治疗对急性缺血性卒中(AIS)患者的硫氧还蛋白(Trx)、中性粒细胞与淋巴细胞比值(NLR)和神经功能的影响。方法选取自2022年1月至2023年12月于句容市人民医院神经内科就诊的120例AIS患者,按照随机数字表法分为试验组(60例)和对照组(60例)。对照组给予常规治疗,试验组在常规治疗基础上加用依达拉奉右莰醇治疗,疗程均为14 d。采用美国国立卫生研究院卒中量表(NIHSS)评估患者的神经系统缺损程度,比较2组患者治疗前和治疗14 d的Trx水平、NLR水平、NIHSS评分和治疗期间的不良反应发生率。结果2组患者治疗前的Trx水平、NLR水平和NIHSS评分比较,差异均无统计学意义(P>0.05)。与本组治疗前比较,2组患者治疗后的Trx、NLR水平和NIHSS评分均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。试验组的总有效率(96.67%)高于对照组(83.33%),差异有统计学意义(P<0.05)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉右莰醇可显著降低AIS患者血清Trx、NLR水平,改善神经功能,且未增加不良反应。Objective To investigate the effects of edaravone dexborneol treatment on thioredoxin(Trx),neutrophil-to-lymphocyte ratio(NLR)and neurological function in patients with acute ischemic stroke(AIS).Methods One hundred and twenty AIS patients who received treatment in the Neurology Department of Jurong People&apos;s Hospital from January 2022 to December 2023 were divided into the experimental group(60 cases)and the control group(60 cases)through the random number table method.The control group was given conventional treatment,and the experimental group was treated with edaravone dexborneol in addition to conventional treatment,with a treatment duration of 14 d for both groups.The National Institutes of Health stroke scale(NIHSS)was used to assess the degree of neurological deficit in patients.The Trx levels,NLR levels,NIHSS scores before and after 14 d of treatment,and incidence of adverse reactions during treatment were compared between two groups of patients.Results There was no statistically significant difference in Trx levels,NLR levels,and NIHSS scores between the two groups of patients before treatment(P>0.05).Compared with before treatment,the Trx levels,NLR levels,and NIHSS scores of both groups of patients decreased after treatment,and the experimental group was lower than the control group,with statistically significant differences(P<0.05).The total effective rate of the experimental group(96.67%)was higher than that of the control group(83.33%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Edaravone dexborneol can significantly reduce the level of Trx and NLR in AIS patients,improve neurological function,and do not increase adverse reactions.

关 键 词：急性缺血性卒中 依达拉奉右莰醇 硫氧还蛋白 中性粒细胞与淋巴细胞比值 神经系统功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]