细胞外囊泡在多发性硬化疾病诊断中的新进展  

New advances in the diagnosis of multiple sclerosis with extracellular vesicles

作　　者：张志勔 李晓玲[2] Zhimian Zhang;Xiaoling Li(Department of Neurology,The Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Rehabilitation Medicine,The Second Hospital&Clinical Medical School,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院(第二临床医学院)神经内科,兰州730000 [2]兰州大学第二医院(第二临床医学院)康复医学科,兰州730000

出　　处：《中华脑科疾病与康复杂志(电子版)》2024年第6期373-378,共6页Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition)

基　　金：国家自然科学基金(82360254);甘肃省科技计划项目(24JRRA359);兰州市城关区科技计划项目(2023RCCX0012)

摘　　要：细胞外囊泡(EV)作为细胞间信息传递的重要介质,可以稳定携带蛋白质、脂质、核酸等物质,其表面与亲代细胞含有共同的特异性标志,可以作为高度敏感性的特异性生物标志物用于临床诊断。多发性硬化(MS)是中枢神经系统自身免疫性炎性脱髓鞘疾病,尚无特异性的诊断标志物,近年来MS的发病率和患病率呈逐渐增高的趋势。EV可以用来协助明确MS的临床诊断、甄别临床分型、监控疾病复发、推测疾病预后,受到了越来越多的关注。本文围绕EV在MS临床诊断中的应用展开综述。Extracellular vesicles(EV),as important mediators of intercellular communication,can stably carry proteins,lipids,nucleic acids,and other substances.Their surface shares specific markers with the parent cells,making them highly sensitive and specific biomarkers for clinical diagnosis.Multiple sclerosis(MS)is an autoimmune inflammatory demyelinating disease of the central nervous system,and there are currently no specific diagnostic markers for it.In recent years,the incidence and prevalence of MS have gradually increased.EV can assist in clarifying the clinical diagnosis of MS,distinguishing clinical subtypes,monitoring disease relapse,and predicting disease prognosis,which has attracted increasing attention.This article reviews the application of EV in the clinical diagnosis of MS.

关 键 词：细胞外囊泡 多发性硬化 诊断 疾病分型 复发 预后 

分 类 号：R744.5[医药卫生—神经病学与精神病学]