Etanercept:A viable treatment option for young children with generalized pustular psoriasis  

作　　者：Yunliu Chen Zhaoyang Wang Chaoyang Miao Zigang Xu Xin Xiang 

机构地区：[1]Department of Dermatology,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China

出　　处：《Pediatric Investigation》2024年第4期295-298,共4页儿科学研究(英文)

基　　金：National Key R&D Program of China,Grant/Award Number:2023YFC2508101;Beijing Hospitals Authority’s Ascent Plan,Grant/Award Number:DFI20241201

摘　　要：Generalized pustular psoriasis(GPP)is a severe inflammatory cutaneous disease characterized by widespread pustules,edema,erythema,fever,and systemic inflammation.Chinese data indicate that the prevalence and incidence of GPP follow a bimodal age distribution,with peaks in the 0–3 year age group and the 30–39 year age group.1 In the 0–3 year age group,the prevalence was 0.927 and the incidence rate was 0.742 per 100000 population-years.1 Interleukin(IL)-36 plays an important role in GPP by activating nuclear factor-κB(NF-κB)and mitogen-activated protein kinase(MAPK)signal pathways.2 Chemokines(CXCL8,CXCL1,CXCL2,etc.),cytokines(IL-1β,tumor necrosis factor TNF-α,IL-6,IL-23,IL-17,etc.),and activated cells(e.g.,keratinocyte,neutrophils,dendritic cells,etc.)are also involved.3 Acitretin,cyclosporine,methotrexate,and etanercept were recommended as first-line treatments for children with GPP in 2012 by the American National Psoriasis Foundation.4 However,recent findings suggest that biological agents targeting IL-36,TNF-α,IL-17,IL-23,or their receptors might be more promising options than conventional drugs.5 Clinical trials and case series have also demonstrated the superiority of biological agents in adult and older pediatrics with GPP,including spesolimab,etanercept,adalimumab,secukinumab,brodalumab,and others.6 However,these biological agents,have only been approved by the FDA for children aged 4 years or older,and there is still limited data on their use in GPP patients under 4 years old.

关 键 词：severe inflammatory cutaneous disease generalized pustular psoriasis TNF children ETANERCEPT generalized pustular psoriasis gpp IL activating nuclear f 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]