Role of childhood trauma in psychogenic non-epileptic seizures: a report from China  

作　　者：Xin Tong Rong Luo Xiao Hu Dong Zhou Dongmei An 

机构地区：[1]Department of Neurology,West China Hospital,Sichuan University,No.37 Guoxue Road,Chengdu 610041,Sichuan,China [2]Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,Sichuan University,Sichuan University,Chengdu 610041,China [4]Department of Rehabilitation Medicine,West China Second University Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Acta Epileptologica》2025年第1期57-67,共11页癫痫学报(英文)

基　　金：supported by the National Natural Science Foundation of China(82101523,82171443 and 81771402);Sichuan International Science and Technology Innovation Cooperation/Hong Kong,Macao and Taiwan Science and Technology Innovation Cooperation Project(2021YFH0136);the 1.3.5 project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(2019HXFH047).

摘　　要：Background To investigate the prevalence,risk factors,and impacts of childhood trauma in Chinese patients with psychogenic non-epileptic seizures(PNES)compared to the healthy population.Methods Patients with PNES and sex-and age-matched healthy controls were recruited.All the participants were interviewed to collect demographics,information of childhood environment,and clinical characteristics.Each participant completed the Childhood Trauma Questionnaire-Short Form(CTQ-SF),the Dissociative Experiences Scale(DES),and the Symptom Checklist-90(SCL-90).Factors associated with childhood trauma,psychiatric symptoms,and clinical features of PNES were analyzed.Results A total of 35 PNES patients and 34 controls were included in this study.Compared with the controls,the PNES patients reported a higher rate of childhood trauma and more severe psychiatric symptoms.In the PNES patients,early separation from parents was related to more types of childhood trauma and emotional neglect(EN);older age and rural residence during childhood were related to sexual abuse(SA).Moreover,childhood SA and trauma accumulation were correlated with the present psychiatric symptoms.Childhood trauma and rural residence were associated with dissociative symptoms.Separation from parents predicted an earlier PNES onset,whereas childhood SA predicted a later onset.More severe dissociative symptoms were associated with higher seizure frequency.Conclusions Childhood trauma is related to the development of PNES and the compromised mental health in PNES patients.This highlights the importance of child protection for preventing psychiatric disorders such as PNES.

关 键 词：Psychogenic non-epileptic seizures Risk factor Childhood trauma Mental health Parent-child separation Dissociative symptoms 

分 类 号：R57[医药卫生—消化系统]