Whether radiofrequency thermocoagulation guided by stereotactic electroencephalography can benefit drug-resistant epilepsy in the early follow-up stage  

作　　者：Jingtao Yan Yuhao Wang Le Wang Weipeng Jin Chuan Du Guangfeng Li Deqiu Cui Shaoya Yin 

机构地区：[1]Clinical College of Neurology,Neurosurgery and Neurorehabilitation,Tianjin Medical University,Tianjin 300350,China [2]Department of Neurosurgery,Jin Cheng People’s Hospital,Jincheng City,Shanxi Province 048026,China [3]Department of Neurosurgery,Huanhu Hospital,Tianjin University,Tianjin 300350,China

出　　处：《Acta Epileptologica》2025年第1期105-113,共9页癫痫学报(英文)

基　　金：supported by National Key R&D Program of China(2021YFF1200700).

摘　　要：Background Stereotactic electroencephalography(SEEG)has emerged as a widely utilized diagnostic approach in epilepsy surgery,demonstrating broad clinical applications and a favorable safety profile.SEEG,when combined with radiofrequency thermocoagulation(RF-TC),facilitates the identification of epileptogenic zones and serves as a therapeutic option that eliminates the need for general anesthesia,thus incuring no additional costs for patients.This study aimed to investigate whether SEEG-guided RF-TC provides early therapeutic benefits.Methods A retrospective analysis was performed on 44 patients with drug-resistant epilepsy who underwent RF-TC treatment between April 2019 and December 2022,with complete follow-up data available.RF-TC was administered after the recording three or more habitual epileptic seizures in all patients.Demographic characteristics were retrospectively assessed,and treatment outcomes were evaluated using the Engel classification system.Results SEEG-guided RF-TC treatment was successfully performed in all patients without significant neurological complications.An average of 7.7±0.4 electrodes were implanted per patient,with a SEEG monitoring duration of 7.5 days(range:6.8–11).Follow-up after thermocoagulation ranged from 9 to 63 months.At the three-month follow-up,56.8%of patients achieved Engel I(11 cases)and II(14 cases)were included.At the six-month follow-up,40.9%of patients achieved Engel grades I(9 cases)and II(9 cases),with five patients proceeding to surgical treatment.By the 12-month follow-up,40.9%of patients reached Engel grades I(5 cases)and II(13 cases),with a cumulative total of 12 patients undergoing surgical intervention.At the 24-month follow-up,20.5%of patients achieved Engel grades I(3 cases)and II(6 cases),resulting in a cumulative total of 16 patients undergoing surgical treatment.A statistically significant reduction in seizure frequency was observed before and after thermocoagulation in all 44 patients(P=0.007),although the therapeutic effect of thermocoagulation dec

关 键 词：RF-TC guided by SEEG Drug resistant epilepsy Engel grading 

分 类 号：R74[医药卫生—神经病学与精神病学]