m6A甲基阅读蛋白YTHDF3调控肿瘤发生发展的研究进展  

Research progress on m6A methylation reader protein YTHDF3 and its regulation of cancer initiation and progression

作　　者：黄悠阳 赵然尊 Huang Youyang;Zhao Ranzun(Department of Cardiology,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院心血管内科,贵州遵义563000

出　　处：《遵义医科大学学报》2025年第3期318-324,共7页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81960066)。

摘　　要：N~6甲基腺苷化(m6A)是真核细胞中最常见的一种RNA转录后修饰。作为m6A修饰中的重要甲基阅读蛋白,YTH N~6甲基腺苷RNA结合蛋白3 (YTHDF3)能够识别m6A修饰后的下游靶基因,并参与对这些基因表达的调控。目前的研究表明,YTHDF3在癌症的发生发展中有着重要作用,包括影响癌细胞的迁移能力、上皮细胞间质转化以及血管生成等。YTHDF3可能成为癌症诊断和药物研发新的分子靶点,为肿瘤的诊断和治疗提供了新思路和方向。本文旨在综述YTHDF3在癌症中的研究进展,为m6A修饰在癌症临床治疗研究中提供新的研究思路和治疗靶点。Objective N6-methyladenosine(m6A)is the most prevalent post-transcriptional modification of RNA in eukaryotic cells.As a crucial methyl reader protein involved in m6A modification,YTH N6-methyladenosine RNA binding protein F3(YTHDF3)can identify downstream target genes following m6A modification and participate in the regulation of gene expression.Current research suggests that YTHDF3 plays a pivotal role in the onset and progression of cancer,influencing cancer cell migration,epithelial-mesenchymal transition,and angiogenesis.YTHDF3 has the potential to emerge as a novel molecular target for cancer diagnosis and drug development,offering fresh insights and directions for tumor diagnosis and treatment.This article aims to comprehensively review the research advancements of YTHDF3 in cancer,presenting novel research concepts and treatment targets for the clinical investigation of m6A modification in cancer therapy.

关 键 词：N~6甲基腺苷化 YTH N~6甲基腺苷RNA结合蛋白3 癌症治疗 

分 类 号：R730.2[医药卫生—肿瘤]