胰腺癌瘤内微生物调控肿瘤相关巨噬细胞极化的研究进展  

Research Progress on Regulation of Tumor-Associated Macrophages Polarization by Intratumoral Microorganisms in Pancreatic Cancer

作　　者：鄢雅纤 王玮[2] YAN Yaxian;WANG Wei(College of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China;Department of Gastroenterology,Xiangyang Central Hospital,Hubei University of Arts and Science,Xiangyang 441000,China)

机构地区：[1]武汉科技大学医学部医学院,武汉430065 [2]湖北文理学院附属襄阳市中心医院消化内科,襄阳441000

出　　处：《肿瘤防治研究》2025年第3期241-246,共6页Cancer Research on Prevention and Treatment

基　　金：湖北省教育厅科研计划指导性项目(B2020139)。

摘　　要：近年来研究发现胰腺癌中存在特定的微生物,越来越多的证据显示微生物组的改变与胰腺癌肿瘤免疫功能之间存在关联,肿瘤微环境(TME)中的不同刺激促使肿瘤相关巨噬细胞(TAM)向免疫激活的M1表型或免疫抑制的M2表型极化,TME中的微生物通过影响巨噬细胞的表型和功能促进或抑制肿瘤生长、转移和耐药等过程。本文对胰腺癌TME中的几种厌氧菌调控TAM极化的作用机制进行了综述,就细菌菌体成分和代谢产物对TAM极化的影响进行了讨论,以期从微生物的视角为胰腺癌的诊断及治疗提供新的靶点。Recent studies have revealed the presence of specific microorganisms in pancreatic cancer.Accumulating evidence suggests a correlation between changes in the microbiome and tumor immune function in pancreatic cancer.Various stimuli within the tumor microenvironment(TME)prompt the polarization of tumor-associated macrophages(TAMs)toward the immune-activating M1 phenotype or immunosuppressive M2 phenotype.Microorganisms in the TME can facilitate or inhibit tumor growth,metastasis,drug resistance,and other processes by influencing the phenotypes and functions of macrophages.This article reviews the mechanisms by which anaerobic bacteria regulate TAM polarization in the TME of pancreatic cancer.Additionally,it discusses the effects of bacterial components and metabolites on TAM polarization,aiming to provide new targets for the diagnosis and treatment of pancreatic cancer from a microbial perspective.

关 键 词：胰腺癌 瘤内微生物 肿瘤相关巨噬细胞 肿瘤微环境 

分 类 号：R735.9[医药卫生—肿瘤]