OCT predictors of retinal atrophy in neovascular agerelated macular degeneration treated with aflibercept  

作　　者：Oscar MGagliardi Ludovico Alisi Giacomo Visioli Federica Dini Giuseppe MAlbanese Stefano Scordari Marco Marenco Alessandro Lambiase Rosalia Giustolisi 

机构地区：[1]Department of Sense Organs,Sapienza University of Rome,Viale del Policlinico 155,Rome 00161,Italy [2]Department of Neurosciences,Psychology,Drug Research and Child Health Eye Clinic,University of Florence,Viale Pieraccini 6,Florence 50139,Italy

出　　处：《International Journal of Ophthalmology(English edition)》2025年第4期648-655,共8页国际眼科杂志(英文版)

摘　　要：AIM:To identify optical coherence tomography(OCT)features present at the diagnosis of neovascular age-related macular degeneration(nAMD)that could predict retinal atrophy(RA)and visual performance in patients treated with intravitreal aflibercept.METHODS:OCT data collected at the time of nAMD diagnosis(T0),after the first(T1)and third(T2)intravitreal aflibercept injection,and 5y post-diagnosis(T3)were analyzed.The study included 46 eyes from patients undergoing treatment.The association of OCT features with RA and visual acuity(VA)development over time were evaluated.RESULTS:Patients with RA at T3 exhibited worse VA(35.19±5.7 vs 8.90±2.3,P<0.001)and a lower rate of improvement or stability at T2(90.48%vs 56.00%,P=0.019)and T3(85.71%vs 8.00%,P<0.001).The development of RA at T3 was linked with type 2 macular neovascularization(MNV;4.76%vs 36.00%,P=0.013),thinner outer nuclear layer(ONL,88.89±7.82μm vs 71.38±14.14μm,P=0.033),presence of intraretinal fluid(IRF,42.86%vs 80.00%,P=0.014),presence of IRF without subretinal fluid at T0(SRF,4.76%vs 32.00%,P=0.027),and reduced central foveal thickness at T3(CFT,190.14±22.79μm vs 124.32±14.35μm,P<0.001).The presence of SRF with or without IRF at the diagnosis was comparable between the two groups(90.48%vs 68.00%;P=0.084).CONCLUSION:Type 2 MNV,reduces ONL and CFT,and IRF presence at baseline may signal a higher risk of RA in treatment-naive nAMD patients,underscoring the importance of these OCT features in early risk assessment and management strategies.

关 键 词：neovascular age-related macular degeneration long-term prognosis optical coherence tomography OCT predictors retinal atrophy 

分 类 号：R73[医药卫生—肿瘤]