Reduction of photoreceptor cell packing density in low or moderative myopia detected with adaptive optics scanning laser ophthalmoscopy  

作　　者：Lin-Yi Lei Yue Zhao Tang-Ren Cai Si-Guo Feng Jin Yao 

机构地区：[1]The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China [2]The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing 210029,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第4期683-690,共8页国际眼科杂志(英文版)

基　　金：Supported by National Natural Science Foundation of China(No.82271107).

摘　　要：AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ophthalmoscopy(AOSLO)systems were utilized for retinal imaging with a large sampling window of 700μm×700μm.The study cohort included 14 emmetropic[spherical equivalent(SE)ranged+0.5 to-0.5 D],15 low myopic(SE ranged-0.5 to-3 D)and 21 moderate myopic(SE ranged-3 to-6 D)healthy young adults.Photoreceptors at 3°temporal,6°superior and inferior 6°were captured.Statistical analysis was then performed to obtain PCPD and cell spacing.RESULTS:The average age of participants was 22.54±2.86(ranged 20–30y)with no difference among 3 groups.At 3°temporal,the emmetropic group exhibited the highest PCPD of 15186.16±2050.54 cells/mm2,while the low and moderate myopic groups had PCPD of 14009.15±1073.01 and 13466.92±1121.71 cells/mm2,respectively.At 3°temporal,the emmetropic group also had the smallest cell spacing at 6.66±0.26 mm,compared to 6.85±0.26 and 6.91±0.28 mm for the low and moderate myopic groups,respectively.Compared to the emmetropic group,at 3°temporal,the myopic groups showed significantly reduced PCPD(low myopia:P=0.032;moderate myopia:P=0.001).At 6°inferior,the moderate myopic group exhibited a significant decrease in PCPD(P=0.013),while at 6°superior,there were no significant statistical differences in PCPD for the low and moderate myopic groups(P>0.05).In comparison to the emmetropic group,only the moderate myopic group showed significantly increased cell spacing at all three positions(temporal 3°:P=0.011,superior 6°:P=0.046,inferior 6°:P=0.013).Correlation analysis revealed a positive correlation between PCPD and axial length changes(P<0.05).CONCLUSION:Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes,especially at 6°inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be as

关 键 词：adaptive optics scanning laser ophthalmoscopy photoreceptor cell packing density FOVEA refractive error MYOPIA 

分 类 号：R73[医药卫生—肿瘤]