时间干涉刺激干预精神分裂症工作记忆缺陷有效性与脑区特异性及跨频耦合机制  

The effectiveness and brain region specificity of temporal interference stimulation for working memory deficits in schizophrenia and the mechanism of cross-frequency coupling

作　　者：邓虎 符艳冉 吴刚 DENG Hu;FU Yanran;WU Gang(Peking University Huilongguan Clinical Medical School,Beijing Huilongguan Hospital,Beijing 100096,China;The Second People's Hospital of Guizhou Province,Guiyang 550004,China)

机构地区：[1]北京回龙观医院/北京大学回龙观临床医学院,北京100096 [2]贵州省第二人民医院,贵阳550004

出　　处：《心理科学进展》2025年第4期620-631,共12页Advances in Psychological Science

基　　金：国家自然科学基金(82301693);北京市医院管理中心“登峰”人才培养计划(DFL20221701)。

摘　　要：工作记忆缺陷是精神分裂症核心临床特征之一,它与顶下小叶和背外侧前额叶θ节律及跨频耦合密切关联。相比于传统经颅交流电等脑节律调控手段,时间干涉刺激(Temporal interference stimulation,TIs)具有靶向聚焦和诱导特定神经响应等特征,为通过精准节律调控改善工作记忆缺陷提供可能性。本研究拟验证TIs临床干预有效性、脑区特异性并探索其作用机制。研究将入组100例首发精神分裂症患者,随机分成4组,分别予以靶向顶下小叶的θ振荡TIs和传统经颅交流电及各自伪刺激,在干预前后收集行为与脑电数据,验证TIs干预精神分裂症的工作记忆缺陷有效性并对比传统经颅交流电疗效。然后,通过对比背外侧前额叶和顶下小叶靶点的TIs效果探索其疗效的脑区特异性。最后,从跨频耦合等多角度探究行为改变的脑电机制。本研究的实施有望为精神分裂症的工作记忆缺陷治疗提供新选择和理论支撑,为TIs干预工作记忆缺陷机理解析提供多维证据,奠定临床基础。Working memory deficit(WMD)represents a pivotal clinical feature of schizophrenia(SCZ).The mechanisms of theta oscillation and cross-frequency coupling in the inferior parietal lobule(IPL)and dorsolateral prefrontal lobe(DLPFC)are closely associated with WMD.Previous neuromodulation tools,such as transcranial alternating current stimulation(tACS),have been demonstrated to be inadequate in terms of both focality and treatment efficacy in the context of working memory improvement.Temporal interference stimulation(TIs),which has high focality and the capacity to induce specific neural oscillations,offers a potential avenue for precise intervention in the improvement of WMD.The objective of this project is to provide evidence to verify the effectiveness,brain region specificity and cross-frequency coupling mechanism of clinical intervention for TIs.The study will randomly assign 100 patients with first-episode schizophrenia to one of four groups.Each group will receive a different intervention:theta oscillation of TIs,theta oscillation of tACS,pseudo-stimulation of TIs,or pseudo-stimulation of tACS.The target areas for all groups are the inferior parietal lobule.Moreover,we will gather data on working memory performance and EEG readings from SCZ patients before and after the intervention to ascertain the efficacy of TIs in improving WMD.Furthermore,the efficacy of this approach will be compared to that of tACS.Then,the target area for the theta oscillation of TIs will be transferred to the DLPFC in a new cohort of SCZ patients.By comparing the effects of TIs targeting the DLPFC and IPL,this project will provide evidence regarding the brain region specificity of TIs.Finally,this project will elucidate the EEG mechanisms underlying the effectiveness and brain region specificity of TIs intervention from multiple perspectives,such as cross-frequency coupling.This study will provide a new therapeutic tool and theoretical insights for schizophrenia.

关 键 词：精神分裂症 工作记忆 时间干涉刺激 脑区特异性 跨频耦合 

分 类 号：R749[医药卫生—神经病学与精神病学]