原发性肺淋巴瘤63例临床特征分析  

Clinical characteristics analysis of 63 cases of primary pulmonary lymphoma

作　　者：丁文秋 张甲燚 何梦钰 DING Wenqiu;ZHANG Jiayi;HE Mengyu(Department of Respiratory&Critical Care Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)

机构地区：[1]南京医科大学第一附属医院呼吸与危重症医学科,江苏南京210029

出　　处：《临床肺科杂志》2025年第4期492-497,共6页Journal of Clinical Pulmonary Medicine

基　　金：国家自然科学基金(82000061)。

摘　　要：目的探讨原发性肺淋巴瘤(primary pulmonary lymphoma,PPL)的临床特征,提高临床医生对原发性肺淋巴瘤的认识。方法回顾性分析2016年3月至2023年4月就诊于南京医科大学第一附属医院的63例原发性肺淋巴瘤患者的临床资料。结果63例患者均通过病理学和免疫组织化学确诊,其中有6例诊断为霍奇金淋巴瘤(Hodgkin lymphoma,HL)和57例诊断为非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)。63例患者男女比例为1.25∶1,年龄为(54.0±14.2)岁。影像学多表现为孤立性肿块、多发结节、肿块或实变,其中17例患者胸部CT可见支气管充气征,17例患者合并胸腔积液。34例患者接受18F-FDG PET/CT检查,病灶的平均SUVmax为11.4±8.1。53例患者经CT引导的经皮肺穿刺活检诊断,5例由纤维支气管镜检查行病灶活检诊断,2例由超声内镜引导下的经支气管针吸活检(endobronchial ultrasound-transbronchial needle aspiration,EBUS-TBNA)诊断,3例由外科手术后诊断。结论原发性肺淋巴瘤是一种罕见的疾病,临床表现不典型,常被误诊。CT是协助诊断原发性肺淋巴瘤的有效方法,但仍需病理活检和免疫组织化学确诊及分型。Objective To investigate the clinical characteristics of pulmonary primary pulmonary lymphoma(PPL)and improve the understanding of clinicians on PPL.Methods The clinical data of 63 patients with primary pulmonary lymphoma admitted to the First Affiliated Hospital of Nanjing Medical University from March 2016 to April 2023 were retrospectively analyzed.Results 63 patients were confirmed by pathology and immunohistochemistry,6 of who 6 were diagnosed with Hodgkin lymphoma(HL)and 57 were diagnosed with non-Hodgkin lymphoma(NHL).The male to female ratio was 1.25:1,and the age was(54.0±14.2)years old.Most of the imaging findings were isolated masses,multiple nodules,masses or consolidation.Among them,17 patients showed pneumobronchial signs on chest CT,and 17 patients combined with pleural effusion.The 34 patients underwent 18F-FDG PET/CT examination,and the mean SUVmax of the lesions was 11.4±8.1.53 patients were diagnosed by CT-guided percutaneous pulmonary puncture biopsy,5 by fibrobronchoscopy,2 by endobronchial ultrasound-transbronchial needle aspiration(EBUS-TBNA),and 3 by surgery.Conclusion Primary pulmonary lymphoma is a rare disease with atypical clinical manifestations and is often misdiagnosed.CT is an effective method to assist in the diagnosis of primary pulmonary lymphoma,but it still needs pathological biopsy and immunohistochemical confirmation and classification.

关 键 词：原发性肺淋巴瘤 临床特征 回顾性研究 

分 类 号：R73[医药卫生—肿瘤]