表现为磨玻璃结节的肺腺癌的影响因素研究  

Study on the influencing factors of lung adenocarcinoma manifested as ground glass nodules

作　　者：赵田 王桥 康佳敏 夏广梅 墨勉勉 张昊 薛凯凯 ZHAO Tian;WANG Qiao;KANG Jiamin;XIA Guangmei;MO Mianmian;ZHANG Hao;XUE Kaikai(Department of Thoracic Surgery,Shanghai Dongfang Hospital,Shanghai 200120,China;Department of Thoracic Surgery,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China;Department of Cardiothoracic Surgery,Xuzhou Cancer Hospital,Xuzhou,Jiangsu 221005,China;School of Nursing,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China)

机构地区：[1]上海市东方医院胸外科,上海200120 [2]徐州医科大学附属医院胸外科,江苏徐州221002 [3]徐州市肿瘤医院心胸外科,江苏徐州221005 [4]徐州医科大学护理学院,江苏徐州221004

出　　处：《临床肺科杂志》2025年第4期520-526,共7页Journal of Clinical Pulmonary Medicine

摘　　要：目的本研究探索表现为磨玻璃结节的肺腺癌的影响因素,为疾病预防提供依据。方法选择徐州医科大学附属医院、徐州市中心医院2020年1-12月内诊断为磨玻璃结节,经手术切除后病理诊断为肺腺癌的患者为观察组(n=100),选择同时期在上述两家医院做健康体检的成年健康人群为对照组(n=100),采用病例对照研究,自制调查问卷收集研究对象的年龄、性别、生活习惯、居住环境、个人史、疾病史、临床特征等数据,使用C型行为量表评估研究对象的性格特征。通过SPSS 16.0进行单因素分析和二分类Logistic多因素回归分析,得出磨玻璃样肺腺癌的影响因素。结果通过单因素分析筛选出在观察组与对照组之间差异有统计学意义(P<0.05)的变量进行Logistic回归分析,得到与磨玻璃样肺腺癌相关的因素为吸二手烟(OR:9.793,95%CI:2.601~36.871)、住房空气湿度大(OR:0.005,95%CI:0.001~0.027)、暴露于厨房油烟(OR:4.862,95%CI:1.511~15.646)、常吃大蒜(OR:7.327,95%CI:2.057~26.093)、家族史(OR:12.355,95%CI:2.105~72.530)、乐观(OR:0.714,95%CI:0.567~0.900)。结论表现为磨玻璃样结节的肺腺癌的危险因素包括吸二手烟、暴露于厨房油烟、肺癌家族史,保护因素为住房空气湿度适宜、乐观。为降低肺腺癌发生的风险,应减少吸二手烟和暴露于厨房油烟环境,居住环境保持适宜的湿度,调整心态,保持积极乐观的情绪。Objective To explore the influencing factors of lung adenocarcinoma manifested as ground glass nodules and provide a basis for disease prevention.Methods Patients diagnosed with ground-glass nodules and pathologically diagnosed with lung adenocarcinoma after surgical resection from January to December 2020 at the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital were selected as the observation group(n=100),and healthy adult individuals who underwent physical examinations at the two hospitals during the same period were selected as the control group(n=100).A case-control study was conducted,and a self-designed questionnaire was used to collect their age,gender,lifestyle,living environment,disease history,clinical characteristics,and other data to evaluate the personality traits of the participants using the C-type behavior scale.Single factor analysis and binary logistic multiple factors regression analysis were conducted by SPSS 16.0 to identify the influencing factors of ground-glass nodule lung adenocarcinoma.Results Through univariate analysis,variables with statistically significant differences(P<0.05)between the observation group and the control group were selected for logistic regression analysis.The factors associated with ground glass lung adenocarcinoma were found to be second-hand smoke exposure(OR:9.793,95%CI:2.601-36.871),high air humidity in housing(OR:0.005,95%CI:0.001-0.027),exposure to kitchen fumes(OR:4.862,95%CI:1.511-15.646),frequent consumption of garlic(OR:7.327,95%CI:2.057-26.093),family history(OR:12.355,95%CI:2.105-72.530)and optimistic(OR:0.714,95%CI:0.567-0.900).Conclusion The risk factors of lung adenocarcinoma manifested as ground glass nodules include second-hand smoke,exposure to kitchen fumes,and a family history of lung cancer.The protective factors are optimistic and appropriate air humidity in the housing.To reduce the risk of ground glass like lung adenocarcinoma,it is necessary to reduce secondhand smoke and exposure to kitchen fumes,maintain appropr

关 键 词：肺磨玻璃结节 肺腺癌 肺癌 病例对照研究 

分 类 号：R73[医药卫生—肿瘤]