化痰通络汤联合头皮针治疗脑梗死疗效观察及对氧化应激、炎症因子水平的影响  

Observation on Curative Effect of Huatan Tongluo Decoction Combined with Scalp Acupuncture on Cerebral Infarction and Its Effects on Oxidative Stress and Inflammatory Factors

作　　者：罗恒 唐晓飞 张军莉 LUO Heng;TANG Xiaofei;ZHANG Junli(Neurological Department,Hangzhou Fuyang Hospital of Traditaional Chinese Medicine,Hangzhou Zhejiang 311400,China)

机构地区：[1]杭州市富阳区中医院神经内科,浙江杭州311400

出　　处：《新中医》2025年第6期36-40,共5页New Chinese Medicine

基　　金：杭州市科技计划引导项目(20211231Y172)。

摘　　要：目的:观察化痰通络汤联合头皮针治疗脑梗死的临床疗效及对氧化应激、炎症因子水平的影响。方法:选择2022年1月—2024年1月杭州市富阳区中医院收治的62例脑梗死病历资料进行回顾性分析,按不同的治疗方法分为对照组30例和观察组32例。2组均接受西医常规治疗,对照组加用头皮针治疗,观察组加用化痰通络汤联合头皮针治疗。观察2组临床疗效及不良反应发生情况,比较2组治疗前后神经功能[美国国立卫生研究院脑卒中量表(NIHSS)评分、简易精神状态检查量表(MMSE)评分]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、总抗氧化能力(T-AOC)]、炎症因子[高迁移率族蛋白B1(HMGB1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果:治疗后,观察组总有效率为84.38%(27/32),对照组为60.00%(18/30),2组比较,差异有统计学意义(P<0.05)。治疗后,2组NIHSS评分均较治疗前降低(P<0.05),MMSE评分较治疗前升高(P<0.05);且观察组NIHSS评分低于对照组(P<0.05),MMSE评分高于对照组(P<0.05)。治疗后,2组MDA水平较治疗前降低(P<0.05),SOD、T-AOC水平较治疗前升高(P<0.05);且观察组MDA水平低于对照组(P<0.05),SOD、T-AOC水平高于对照组(P<0.05)。治疗后,2组HMGB1、TNF-α、IL-6水平均较治疗前降低(P<0.05),且观察组3项指标水平均低于对照组(P<0.05)。治疗期间,观察组不良反应发生率为9.38%(3/32);对照组为3.33%(1/30),2组比较,差异无统计学意义(P>0.05)。结论:在西医常规治疗的基础上,化痰通络汤联合头皮针治疗脑梗死可提高临床疗效,有效减轻氧化应激及炎症反应,促进患者神经功能恢复。Objective:To observe the clinical effect of Huatan Tongluo Decoction combined with scalp acupuncture on cerebral infarction and its effects on the levels of oxidative stress and inflammatory factors.Methods:A retrospective analysis was conducted on 62 cases of patients with cerebral infarction treated at Hangzhou Fuyang Hospital of Traditaional Chinese Medicine from January 2022 to January 2024.The patients were divided into the control group(30 cases)and the observation group(32 cases)based on different treatment methods.Both groups received conventional western medical treatment;the control group was additionally treated with scalp acupuncture,and the observation group was additionally treated with Huatan Tongluo Decoction combined with scalp acupuncture.Clinical effects and adverse reactions were observed in the two groups.The levels of neurological function[National Institutes of Health Stroke Scale(NIHSS)scores,Mini-Mental State Examination(MMSE)scores],oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA),total antioxidant capacity(T-AOC)],and inflammatory factors[high mobility group protein B1(HMGB1),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]in the two groups were compared before and after treatment.Results:After treatment,the total effective rate was 84.38%(27/32)in the observation group and 60.00%(18/30)in the control group,with a significant difference between the two groups(P<0.05).After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and MMSE scores were increased when compared with those before treatment(P<0.05).The observation group had lower NIHSS score and higher MMSE score compared to the control group(P<0.05).After treatment,MDA levels in the two groups were reduced when compared with those before treatment(P<0.05),and the levels of SOD and T-AOC were increased when compared with those before treatment(P<0.05);the observation group had lower MDA level and higher levels of SOD and T-AOC compared to the control

关 键 词：脑梗死 化痰通络汤 头皮针 美国国立卫生研究院脑卒中量表 简易精神状态检查量表 氧化应激 炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]