精神分裂症患者攻击行为与认知功能、生物标志物的关系分  

Analysis of the Relationship between Aggression Behavior and Cognitive Function and Biomarkers in Patients with Schizophrenia

作　　者：熊静 XIONG Jing(Department of Clinical Psychology,the Third People's Hospital of Yichun,Yichun 336000,China)

机构地区：[1]宜春市第三人民医院临床心理科,江西宜春336000

出　　处：《中国医学创新》2025年第9期155-159,共5页Medical Innovation of China

基　　金：宜春市指导性科技计划项目(JXYC2024KSA158)。

摘　　要：目的:分析精神分裂症患者攻击行为与认知功能、生物标志物的关系。方法:将宜春市第三人民医院2024年1—5月收治的80例精神分裂症患者纳入研究。使用中文版攻击风险筛查量表(V-RISK-10)调查攻击行为,使用蒙特利尔认知评估量表(MoCA)及重复性成套神经心理状态测验(RBANS)调查认知功能,抽取血液样本进行生物标志物[促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT_(3))、游离三碘甲状腺原氨酸(FT_(3))、总甲状腺素(TT_(4))、睾酮(T)、C反应蛋白(CRP)]检测。根据V-RISK-10得分将患者分为攻击组(n=35)和无攻击组(n=45),比较两组认知功能及生物标志物,并使用Pearson相关系数分析V-RISK-10得分与认知功能及生物标志物的相关性。结果:80例精神分裂症患者V-RISK-10平均(8.64±2.39)分,其中低危45例(56.25%),中危18例(22.50%),高危17例(21.25%)。MoCA、RBANS平均分分别为(23.75±3.46)分、(118.69±23.74)分。攻击组MoCA、RBANS得分均低于无攻击组,T、CRP、TT_(4)、FT_(4)、FT_(3)均高于无攻击组,差异均有统计学意义(P<0.05)。两组TSH、TT_(3)比较,差异均无统计学意义(P>0.05)。Pearson相关系数显示:MoCA、RBANS得分与V-RISK-10得分均呈负相关(P<0.05),T、CRP、TT_(4)、FT_(4)、FT_(3)与V-RISK-10得分均呈正相关(P<0.05)。结论:高危攻击行为的精神分裂症患者存在明显认知功能下降及甲状腺激素、T、CRP水平异常。Objective:To analyze the relationship between aggression behavior and cognitive function and biomarkers in patients with schizophrenia.Method:A total of 80 patients with schizophrenia admitted to the Third People's Hospital of Yichun from January to May 2024 were included in the study.The Chinese violence risk screening-10(V-RISK-10)was used to investigate aggressive behavior,the Montreal cognitive assessment(MoCA)and repeatable battery for the assessment of neuropsychological status(RBANS)were employed to assess cognitive function.Blood samples were collected for the detection of biomarkers[thyroid stimulating hormone(TSH),total triiodothyronine(TT_(3)),free triiodothyronine(FT_(3)),total thyroxine(TT_(4)),testosterone(T)and C reactive protein(CRP)].Patients were divided into aggressive group(n=35)and non-aggressive group(n=45)according to V-RISK-10 scores.The cognitive function and biomarkers of the two groups were compared,and the correlation between V-RISK-10 scores and cognitive function and biomarkers were analyzed by Pearson correlation coefficient.Result:The average score of V-RISK-10 of 80 patients with schizophrenia was(8.64±2.39)scores,of which 45 cases(56.25%)were low risk,18 cases(22.50%)were medium risk and 17 cases(21.25%)were high risk.The average scores of MoCA and RBANS were(23.75±3.46)scores and(118.69±23.74)scores,respectively.MoCA and RBANS scores in the aggressive group were lower than those in the non-aggressive group,and T,CRP,TT_(4),FT_(4)and FT_(3)were higher than those in the non-aggressive group,the differences were statistically significant(P<0.05).There were no significant differences in TSH and TT_(3)between the two groups(P>0.05).Pearson correlation coefficient showed that MoCA and RBANS scores were negatively correlated with V-RISK-10 scores(P<0.05),and T,CRP,TT_(4),FT_(4),FT_(3)were positively correlated with V-RISK-10 scores(P<0.05).Conclusion:Schizophrenia patients with high risk aggressive behavior have obvious cognitive decline and abnormal levels of thyroid hormone,T and

关 键 词：精神分裂症 攻击行为 认知功能 甲状腺激素 性激素 C 反应蛋白 

分 类 号：R74[医药卫生—神经病学与精神病学]