花粉诱导的过敏性鼻炎动物模型研究进展  

Progress in animal models of pollen-induced allergic rhinitis

作　　者：徐丹 李姗姗[1] 王毅力 高斐宏 XU Dan;LI Shanshan;WANG Yili;GAO Feihong(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617

出　　处：《中国比较医学杂志》2025年第1期92-110,共19页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82105045)。

摘　　要：花粉变应原诱导的过敏性鼻炎(allergic rhinitis,AR)又称季节性过敏性鼻炎(seasonal allergic rhinitis,SAR),通常发生在风媒植物的花粉散播期。在过去的30年里,SAR的发病率已增加了一倍多。SAR的病因复杂,涉及多种因素,包括花粉变应原的种类、环境气候因素、遗传因素、人体免疫状态等。动物模型是理解AR发病机制和推动有效防治策略发展的重要工具,本文通过总结近年来国内外关于花粉诱导AR动物试验的文献,系统阐述了影响模型效果的因素,包括动物品系、致敏材料(花粉抗原的制作及存在问题、佐剂的使用及存在问题)、造模的步骤和效果评价。这些内容旨在为建立合适的花粉诱导AR动物模型及其相关的基础研究和应用研究提供参考和支持。Pollen allergen-induced allergic rhinitis(AR),also known as seasonal allergic rhinitis(SAR),typically manifests during the period of pollen dissemination by anemophilous plants.The prevalence of SAR has more than doubled over the past three decades.The etiology of SAR is multifaceted,involving factors such as pollen allergens,environmental and climatic conditions,genetic predispositions,and the immunological status of the individual.Animal models provide a critical tool for elucidating the mechanisms underlying AR and advancing the development of effective preventive and therapeutic strategies.This review synthesizes the recent pertinent domestic and international literature on pollen-sensitized AR animal experiments.It systematically delineates the factors influencing the efficacy of these models,including the selection of animal strains,the production and associated challenges of sensitizing agents,specifically pollen antigens,the utilization and limitations of adjuvants,the procedural steps involved in model creation,and the method ologies for evaluating model effectiveness.The insights provided are intended to offer guidance and support for the development of appropriate animal models of pollen-induced AR,thereby facilitating both fundamental and applied research in this area.

关 键 词：季节性过敏性鼻炎 过敏性鼻炎 花粉变应原 动物模型 

分 类 号：R-33[医药卫生]