生酮饮食在帕金森病领域的研究进展  

Research progress on the role of a ketogenic diet in Parkinson’s disease

作　　者：李博阳 兰瑞[2,3] 杨慧捷 李泓宇 李驰阳 沈晓明[2,3] LI Boyang;LAN Rui;YANG Huijie;LI Hongyu;LI Chiyang;SHEN Xiaoming(the First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Encephalopathy Department,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000;Encephalopathy Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院脑病科,郑州450000 [3]河南中医药大学第一附属医院脑病诊疗中心,郑州450000

出　　处：《中国比较医学杂志》2025年第1期111-118,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81973618,81503422);河南省中医药科学研究专项课题(2022JDZX090);河南省自然科学基金(202300410399)。

摘　　要：生酮饮食(ketogenic diet,KD)是指一种饮食模式,旨在促进个体达到低卡路里含量、最低碳水化合物摄入量、高脂肪消耗和标准蛋白质水平。生酮饮食在临床实践应用治疗包括心脏病、糖尿病、肥胖、自闭症、胶质母细胞瘤和其他癌症等。然而,除了癫痫,生酮饮食尚未被推荐用于任何神经系统疾病。近年来随着对生酮饮食的深入研究,越来越多证据证明,生酮饮食对帕金森病(Parkinsons disease,PD)具有神经保护作用,是治疗PD的饮食新疗法。本综述详细论述生酮饮食在帕金森病中不同机制的神经保护作用,旨在对本领域的临床和实验研究提供一定的参考。A ketogenic diet(KD)refers to an eating pattern designed to achieve a low-calorie content,minimum carbohydrate intake,high-fat consumption,and standard protein levels.A ketogenic diet is used in clinical practice to treat conditions including heart disease,diabetes,obesity,autism,glioblastoma,and other cancers.Although a ketogenic diet has not been recommended for any neurological disorders except epilepsy,extensive recent research suggests that such a diet may have a neuroprotective effect and may thus represent a new dietary therapy for the treatment of Parkinson’s disease(PD).In this review,we discuss in detail the mechanisms responsible for the neuroprotective effects of a ketogenic diet in Parkinson’s disease,with the aim of providing references for future clinical and experimental studies.

关 键 词：生酮饮食 帕金森病 酮体 神经保护 

分 类 号：R-33[医药卫生]