铁死亡在子宫内膜异位症中的研究现状  

Current research status of ferroptosis in endometriosis

作　　者：彭佳华[1] 梁瑞宁[1] 宋鑫 孙宇 简晖[1] 罗小泉[1] PENG Jiahua;LIANG Ruining;SONG Xin;SUN Yu;JIAN Hui;LUO Xiaoquan(Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学,南昌330004

出　　处：《中国比较医学杂志》2025年第1期139-146,共8页Chinese Journal of Comparative Medicine

基　　金：江西省自然科学基金(20232BAB216115);江西省教育厅科学技术研究项目(GJJ2200915);江西省中医药管理局科技计划项目(2019A085);江西省研究生创新专项资金(YC2023-B220);中医女性生殖健康及相关疾病研究与转化江西省重点实验室(2024SSY06311);江西中医药大学校级科技创新团队发展计划(CXTD22013)。

摘　　要：子宫内膜异位症(endometriosis,EMs)是全球女性健康面临的常见挑战。近年来,铁死亡作为一种新兴的细胞程序性死亡方式,在EMs研究中备受瞩目。在疾病机制方面,铁死亡通过铁过载诱导,推动卵巢EMs的纤维化,同时通过调控多条信号通路如p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38 MAPK)/信号转导子和转录激活子6(signal transducer and activator of transcription 6,STAT6),促进血管生成、自噬等,加剧病情进展。在不孕问题上,铁死亡影响胚胎发育和卵巢功能,显著降低生育能力。诊断方面,铁死亡相关基因高表达为EMs的早期诊断提供了潜在的标志物,有效区分患者和健康个体,具有重要的临床应用价值。治疗策略上,Erastin等非天然化合物及白藜芦醇、熊果酸和汉黄芩素等天然化合物,展现出潜在的治疗效果,可缓解EMs的病理进程和相关症状。因此,本文通过综述铁死亡在EMs发病机制、不孕问题、诊断和治疗中的多重作用,全面阐述了铁死亡在子宫内膜异位症中的关键作用,探索其作为诊断标志物和治疗靶点的潜力,为EMs的管理提供新的理论支持和治疗策略。Endometriosis presents a common challenge in global women’s health.Ferroptosis,as an emerging form of regulated cell death,has recently attracted attention in relation to endometriosis.In terms of disease mechanisms,ferroptosis drives ovarian endometrial fibrosis via the induction of iron overload,and promotes disease progression by regulating multiple signaling pathways,such as p38 mitogen-activated protein kinase/signal transducer and activator of transcription 6(p38MAPK/STAT6),promote angiogenesis,autophagy,etc,fueling disease progression.In terms of infertility,ferroptosis affects embryo development and ovarian function,thereby reducing fertility.From a diagnostic perspective,high expression of ferroptosis-related genes provides potential biomarkers for the early diagnosis of endometriosis,effectively distinguishing patients from healthy individuals,and showing important clinical value.In terms of treatment strategies,non-natural compounds such as Erastin,as well as natural compounds such as resveratrol,ursolic acid,and baicalein,have shown potential therapeutic effects in relieving the pathological process and related symptoms of endometriosis.This review comprehensively elucidates the key role of ferroptosis in endometriosis in terms of the disease mechanisms,infertility,diagnosis,and treatment,and explores its potential as a diagnostic biomarker and therapeutic target,thus providing new theoretical support and treatment strategies for the management of endometriosis.

关 键 词：铁死亡 子宫内膜异位症 发病机制 

分 类 号：R-33[医药卫生]