SHP2在结肠炎相关性结肠癌与结直肠癌发展中的作用及其作为治疗靶点的研究进展  

Role of SHP2 in development of colitis-associated colon cancer and colorectal cancer and its potential as a therapeutic target

作　　者：张昊 刁庆飞 樊建春 李萌 贾举名 杨春白雪 武雪亮[2,3] ZHANG Hao;DIAO Qingfei;FAN Jianchun;LI Meng;JIA Juming;YANG Chunbaixue;Wu Xueliang(Hebei North University,Zhangjiakou 075000,China;Department of General Surgery,the First AffiliatedHospital of Hebei North University,Zhangjiakou 075000;Cancer Research Institute,the First AffiliatedHospital of Hebei North University,Zhangjiakou 075000)

机构地区：[1]河北北方学院,河北张家口075000 [2]河北北方学院附属第一医院普通外科,河北张家口075000 [3]河北北方学院附属第一医院肿瘤研究所,河北张家口075000

出　　处：《中国比较医学杂志》2025年第1期163-171,共9页Chinese Journal of Comparative Medicine

基　　金：2022年河北省自然科学精准医学联合基金培育项目(H2022405033)。

摘　　要：结直肠癌(colorectal cancer,CRC)作为威胁人类生命最常见的恶性肿瘤之一,其严重影响着患者的生活质量。近年来,SHP2(src homology 2 domain-containing protein tyrosine phosphatase,SHP2)成为癌症领域中备受关注的焦点,已经被证实与CRC有着密切的关系。SHP2,由PTPN11基因编码,是一种非受体酪氨酸激酶,在人体各组织和细胞中普遍存在。现有研究显示,SHP2在调控CRC及结肠炎相关性结肠癌(colitis-associated colon cancer,CAC)中扮演关键角色,并随着SHP2变构抑制剂的出现,SHP2成为了CRC患者新的潜在的治疗靶点。本文主要针对SHP2的结构及其在CRC和CAC中的影响进行综述。Colorectal cancer(CRC)is one of the most common malignant life-threatening tumors,with serious impacts on patient quality of life.Src homology 2 domain-containing protein tyrosine phosphatase(SHP2)has recently become a hot topic in the field of cancer research,and has demonstrated a close relationship with CRC.SHP2,encoded by the PTPN11 gene,is a non-receptor tyrosine kinase commonly present in various tissues and cells of the human body.Existing research shows that SHP2 plays a crucial role in regulating CRC and colitis-associated colon cancer(CAC),and the emergence of SHP2 allosteric inhibitors has identified SHP2 as a potential new therapeutic target for patients with CRC.Here we review the structure of SHP2 and its roles in CRC and CAC.

关 键 词：酪氨酸磷酸酶 SHP2 PTPN11 结直肠癌 结肠炎相关性结肠癌 

分 类 号：R-33[医药卫生]