非小细胞肺癌患者miR-221、miR-630表达及与预后的关系  

Expressions of miR-221 and miR-630 in NSCLC patients and their relationship with prognosis

作　　者：刘战飞 朱文龙 陈勇 杨得振 刘园蔚 李少民[3] LIU Zhan-fei;ZHU Wen-long;CHEN Yong;YANG De-zhen;LIU Yuan-wei;LI Shao-mim(YangLing Demonstraiton Zone Hospital,Yangling 712100,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 710000,China;The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]杨凌示范区医院,陕西杨凌712100 [2]陕西中医药大学附属医院,陕西咸阳710000 [3]西安交通大学第二附属医院,陕西西安710004

出　　处：《实用医院临床杂志》2025年第2期71-74,共4页Practical Journal of Clinical Medicine

基　　金：陕西省重点研发计划项目(编号:S2022-YF-YBSF-0603)。

摘　　要：目的分析非小细胞肺癌(NSCLC)患者miR-221、miR-630表达及与预后的关系。方法选取102例NSCLC患者,测定NSCLC组织与癌旁组织miR-221、miR-630相对表达量,分析NSCLC组织miR-221、miR-630表达与临床病理特征以及预后的关系。结果NSCLC组织miR-221相对表达量高于癌旁组织,miR-630相对表达量低于癌旁组织(P<0.05);不同TNM分期、淋巴结转移情况的患者NSCLC组织miR-221、miR-630相对表达量差异均有统计学意义(P<0.05);miR-221高表达组3年生存率为60.94%(39/64),低于miR-221低表达组的81.58%(31/38)(P<0.05);miR-630高表达组3年生存率为80.00%(32/40),高于miR-630低表达组的61.29%(38/62)(P<0.05);NSCLC组织miR-221、miR-630均为无进展生存期(PFS)的独立影响因素(P<0.05)。结论NSCLC组织miR-221高表达、miR-630低表达均与患者的不良预后有关。Objective To analyze the expressions of miR-221 and miR-630 in patients with non-small cell lung cancer(NSCLC)and their relationship with prognosis.Methods One hundred and two patients with NSCLC were selected.The relative expression levels of miR-221 and miR-630 in NSCLC tissues and adjacent tissues were determined.The relationship between the expressions of miR-221 and miR-630 in NSCLC tissues and the clinicopathological features and prognosis was analyzed.Results The relative expression level of miR-221 in the NSCLC tissues was higher than that in the adjacent tissues(P<0.05)while the relative expression level of miR-630 was lower than that in the adjacent tissues(P<0.05).The relative expression levels of miR-221 and miR-630 in NSCLC tissues were significantly different among patients with different TNM stages and lymph node metastasis(P<0.05).The 3-year survival rate of the miR-221 high expression group was 60.94%(39/64),which was lower than 81.58%(31/38)of the miR-221 low expression group(P<0.05).The 3-year survival rate of the miR-630 high expression group was 80.00%(32/40),which was higher than 61.29%(38/62)of the miR-630 low expression group(P<0.05).miR-221 and miR-630 in NSCLC tissues were independent influencing factors for progression-free survival(PFS)(P<0.05).Conclusions The high expression of miR-221 and the low expression of miR-630 in NSCLC tissues are related to the poor prognosis of the patients.

关 键 词：非小细胞肺癌 MIR-221 miR-630 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]