放射治疗对头部肿瘤患者眼底视网膜血管的影响  

The effects of radiotherapy on fundus retinal blood vessels in patients with head tumors

作　　者：付昱东 刘妙 李杰[2] 高玉英 FU Yu-dong;LIU Miao;LI Jie;GAO Yu-ying(Department of Oncology,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital(Affiliated Hospital of University of Electronic Science and Technology of China),Chengdu 610072,China;Department of Ophthalmology,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital(Affiliated Hospital of University of Electronic Science and Technology of China),Chengdu 610072,China)

机构地区：[1]四川省医学科学院·四川省人民医院(电子科技大学附属医院)肿瘤科,四川成都610072 [2]四川省医学科学院·四川省人民医院(电子科技大学附属医院)眼科,四川成都610072

出　　处：《实用医院临床杂志》2025年第2期75-79,共5页Practical Journal of Clinical Medicine

基　　金：四川省自然科学基金资助项目(编号:2023NSFSC1515)。

摘　　要：目的探讨放射治疗对头部肿瘤患者眼底视网膜毛细血管的影响。方法纳入头部肿瘤患者(放疗组)40例(75眼),选择正常受试者(对照组)36例(73眼)作对照。放疗组患者接受直线加速器放射治疗3个月和6个月后,通过眼部光学相干断层扫描血管成像(OCTA)分析视网膜毛细血管血流密度变化,结果与对照组作对比。结果放疗组患者治疗3个月和6个月后,与对照组相比,浅层视网膜层、深层视网膜层及视网膜层毛细血管血流密度均显著降低,差异有统计学意义(P<0.05)。结论头部肿瘤(排除眼内肿瘤)患者接受放射治疗后3~6个月,眼部OCTA检测到眼底视网膜血流密度降低,为早期筛查放射性视网膜病变提供临床依据。Objective To investigate the effect of radiation therapy on fundus retinal capillaries in patients with head tumors.Methods Forty patients(75 eyes)with head tumors were selected as a radiotherapy group.Another 36 cases(73 eyes)of normal subjects were selected as a control group.After 3 and 6 months of linear gas pedal radiation therapy,the radiotherapy group was analyzed for changes in retinal capillary blood flow density by using ocular optical coherence tomography angiography(OCTA).The results were compared with those of the control group.Results After 3 and 6 months of treatment,the radiotherapy group showed a statistically significant decrease in capillary blood flow density in the superficial retinal layer,deep retinal layer and retinal layer compared with the control group.The differences were statistically significant.Conclusions After 3 to 6 months of radiotherapy,a decrease in fundus retinal blood flow density is found in patients with head tumors(excluding intraocular tumors)by using ocular OCTA examination.The finding provides a clinical basis for the early screening of radiation retinopathy.

关 键 词：放射治疗 头部肿瘤 光学相干断层扫描血管成像检查 视网膜血管 

分 类 号：R730.55[医药卫生—肿瘤]