食管基底细胞样鳞状细胞癌中程序性死亡因子配体及甲基转移酶的表达及意义  

Expression and significance of programmed death factor ligand and methyltransferase in e-sophageal basaloid squamous cell carcinoma

作　　者：魏娉[1] 姜琳娜[1] 安欣[1] 尹峰[1] 何鹏 WEI Pin;JIANG Lin-na;AN Xin;YIN Feng;HE Peng(Department of Pathology,Handan First Hospital,Handan 056002,China)

机构地区：[1]河北省邯郸市第一医院病理科,河北邯郸056002

出　　处：《实用医院临床杂志》2025年第2期140-144,共5页Practical Journal of Clinical Medicine

基　　金：河北省医学科学研究重点课题计划(编号:20181641)。

摘　　要：目的探讨程序性死亡因子配体-1(PD-L1)、赖氨酸甲基转移酶2D(KMT2D)在原发性食管基底细胞样鳞状细胞癌(BSCC)组织中的表达及与患者预后的相关性。方法选取2015年1月至2019年1月我院收治的原发性食管BSCC患者47例,检测患者癌组织及癌旁组织中的PD-L1、KMT2D表达情况,并分析其与临床病理特征和预后的关系,用Kaplan-Meier法进行生存分析,并进行COX多因素分析影响患者预后的危险因素。结果PD-L1、KMT2D在原发性食管BSCC癌组织中的表达率均显著高于癌旁组织(P<0.05)。PD-L1和KMT2D高表达组与低表达组患者的浸润深度、临床分期和淋巴结转移比较,差异有统计学意义(P<0.05),而在性别、年龄、肿瘤大小、分化程度和肿瘤位置方面的差异无统计学意义(P<0.05)。原发性食管BSCC患者PD-L1与KMT2D表达呈正相关(P<0.01)。生存分析结果表明,PD-L1高表达组和PD-L1低表达组5年总生存率分别为12.5%(2/16)、41.9%(13/31),两组间累积总生存率差异有统计学意义(P<0.05);KMT2D高表达组和KMT2D低表达组5年总生存率分别为17.2%(5/29)、55.6%(10/18),累积总生存率差异有统计学意义(P<0.05)。COX多元回归分析显示,肿瘤分期为III~IV期、浸润深度为T4、存在淋巴结转移、PD-L1高表达及KMT2D高表达为影响患者预后的独立危险因素(P<0.05)。结论PD-L1、KMT2D高表达与原发性食管BSCC患者预后不良有密切关系,有望成为食管BSCC预后和诊断的标志物。Objective To investigate the expression of programmed death factor ligand-1(PD-L1)and lysine methyltransferase 2D(KMT2D)in primary basaloid squamous cell carcinoma of the esophagus(BSCC)and their correlation with prognosis of patients.Methods Forty-seven patients with BSCC treated in our hospital from January 2015 to January 2019 were selected.PD-L1 and KMT2D expression in cancerous and adjacent tissues were detected.The correlation between these expressions and clinicopathological features was analyzed.Kaplan-Meier method was used to analyze the survival.COX univariate and multivariate analysis was used to analyze the influencing factors for prognosis of the patients.Results The expressions of PD-L1 and KMT2D in cancer tissues of primary esophageal BSCC were significantly higher than those in para-cancer tissues(P<0.05).There were statistically significant differences in depth of invasion,clinical stage and lymph node metastasis between high and low expression groups of PD-L1 and KMT2D(P<0.05).There was no significant difference in gender,age,tumor size,tumor location and differentiation degree(P>0.05).There was a positive correlation between PD-L1 and KMT2D expression in primary esophageal BSCC patients(P<0.01).Survival analysis results showed that the 5-year overall survival rates of the PD-L1 high expression group and PD-L1 low expression group were 12.5%(2/16)and 41.9%(13/31),respectively.The difference of cumulative overall survival rates between the two groups was significance(P<0.05).The 5-year overall survival rates of the KMT2D high-expression group and the KMT2D low-expression group were 17.2%(5/29)and 55.6%(10/18),respectively.The difference in cumulative overall survival rate between the two groups was statistically significant(P<0.05).COX multivariate regression analysis identified that T4 invasion depth,III to IV tumor stage,lymph node metastasis,high expression of PD-L1,and high expression of KMT2D were independent risk factors affecting the prognosis of patients with primary esophageal BSCC(P<0.0

关 键 词：程序性死亡因子配体-1 赖氨酸甲基转移酶2D 原发性食管基底细胞样鳞状细胞癌 预后 

分 类 号：R730.261[医药卫生—肿瘤]