Hcy、Fib、NSE、SAA在不同严重程度急性脑梗死患者中的表达意义  

Expression Significance of Hcy,Fib,NSE and SAA in Patients with Different Severities of Acute Cerebral Infarction

作　　者：罗婷婷 陈婷 李苹 乐华辉 LUO Tingting;CHEN Ting;LI Ping;YUE Huahui(Department of Clinical Laboratory,First People's Hospital of Fuzhou,Fuzhou 344000,China;不详)

机构地区：[1]抚州市第一人民医院检验科,江西抚州344000 [2]抚州市第一人民医院神经内科,江西抚州344000

出　　处：《中国医学创新》2025年第8期161-165,共5页Medical Innovation of China

基　　金：抚州市指导性科技计划项目(抚科社字[2023]7号第15项)。

摘　　要：目的:探究同型半胱氨酸(homocysteine,Hcy)、纤维蛋白原(fibrinogen,Fib)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、血清淀粉样蛋白A(serum amyloid A,SAA)在不同严重程度急性脑梗死(ACI)患者中的表达意义。方法:选取2023年1月—2024年8月抚州市第一人民医院收治的90例ACI患者纳入观察组,另选同期于该院体检的85例健康志愿者纳入对照组。按照神经功能缺损程度将观察组分为轻度组(≤5分,40例)、中度组(6~14分,30例)、重度组(≥15分,20例)。比较观察组、对照组的基线资料、临床指标差异,比较不同病情严重程度患者的血清Hcy、Fib、NSE、SAA差异;采用Spearman相关系数分析血清Hcy、Fib、NSE、SAA与病情严重程度的相关性;采用受试者操作特征(ROC)曲线评价血清Hcy、Fib、NSE、SAA对ACI患者病情严重程度的预测价值。结果:观察组高血压、糖尿病患者占比均高于对照组,差异均有统计学意义(P<0.05)。重度组、中度组血清Hcy、Fib、NSE、SAA均高于轻度组,重度组血清Hcy、Fib、NSE、SAA均高于中度组,差异均有统计学意义(P<0.05)。Spearman相关系数检验结果显示,ACI患者病情严重程度与血清Hcy、Fib、NSE、SAA水平呈显著正相关(P<0.05);ROC曲线结果显示,Hcy、Fib、NSE、SAA联合检测ACI患者病情严重程度的AUC为0.973,明显高于各项单独预测的0.912、0.887、0.868、0.862。结论:ACI患者Hcy、Fib、NSE、SAA水平伴随病情进展显著升高,Hcy、Fib、NSE、SAA联合检测对于ACI患者病情严重程度具有较高预测价值。Objective:To explore the expression significance of homocysteine(Hcy),fibrinogen(Fib),neuron-specific enolase(NSE)and serum amyloid A(SAA)in patients with acute cerebral infarction(ACI)of different severity.Method:A total of 90 patients with ACI admitted to the First People's Hospital of Fuzhou from January 2023 to August 2024 were included in the observation group,and 85 healthy volunteers who underwent physical examination in the hospital during the same period were included in the control group.According to the degree of neurological impairment,the observation group was divided into mild group(≤5 points,40 cases),moderate group(6-14 points,30 cases),and severe group(≥15 points,20 cases).The differences of baseline data and clinical indexes between the observation group and the control group were compared,and the differences of serum Hcy,Fib,NSE and SAA among patients with different severity of disease were compared.Spearman correlation coefficient was used to analyze the correlation between serum Hcy,Fib,NSE,SAA and the severity of the disease.The predictive value of serum Hcy,Fib,NSE and SAA in the severity of ACI patients was evaluated by receiver operating characteristic(ROC)curve.Result:The proportion of patients with hypertension and diabetes in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Serum Hcy,Fib,NSE and SAA in severe group and moderate group were higher than those in mild group,and serum Hcy,Fib,NSE and SAA in severe group were higher than those in moderate group,the differences were Medical Innovation of China Vol.22,No.8 March,2025 statistically significant(P<0.05).Spearman correlation coefficient test showed that the severity of ACI patients was significantly positively correlated with the levels of serum Hcy,Fib,NSE and SAA(P<0.05).ROC curve results showed that the AUC of the combined detection of Hcy,Fib,NSE and SAA for the severity of ACI patients was 0.973,which was significantly higher than 0.912,0.887,0.868 and 0.862

关 键 词：急性脑梗死 同型半胱氨酸 血浆纤维蛋白原 神经元特异性烯醇化酶 血清淀粉样蛋白A 

分 类 号：R74[医药卫生—神经病学与精神病学]