复方解酒保肝饮料“海量宝”的解酒保肝功效研究  

Study on the Antialcoholic and Liver Protecting Effect of Compound Anti Alcoholic and Liver Protecting Beverage called“HaiLiangBao”

作　　者：邓婷 许友赤 张媛[2] 何云 陈彤[2] DENG Ting;XU Youchi;ZHANG Yuan;HE Yun;CHEN Tong(Fujian Leephick Pharmaceutical Industry Co.,Ltd.,Longyan 364000,China;Longyan University,Longyan 364000,China)

机构地区：[1]福建省力菲克药业有限公司,福建龙岩364000 [2]龙岩学院,福建龙岩364000

出　　处：《现代食品》2025年第2期84-86,99,共4页Modern Food

基　　金：龙岩经开区(高新区)奇迈科技创新基金项目(0000110105)。

摘　　要：以绿豆、甘草、葛根、葛花和枳椇子的提取物为主要原料制备的复方解酒保肝饮料“海量宝”为受试物,通过其对小鼠解酒防醉试验的效果及建立小鼠酒精性肝损伤模型,检测其对酒精性肝损伤的相关指标,评价其对小鼠酒精性肝损伤的保护作用。与空白组对比,其对小鼠醉酒时间差异不显著,对小鼠醉酒潜伏时间显著延长(P<0.05),说明其具有一定防醉作用。与模型组比较,高中低剂量组均显著降低了丙二醛(MDA)、甘油三酯(TG)的含量,显著升高了还原型谷胱甘肽(GSH)水平;各剂量组对肝组织病理改变情况也均有不同程度减轻,其中低剂量组的改变程度最为明显。因此受试物具有一定防醉作用及对酒精性肝损伤具有一定保护作用。A compound sobering and hepatoprotective beverage prepared mainly from extracts of mung bean,licorice,kudzu root,kudzu flower,and juvenia dulcis was used as the test substance.Its effects on sobering and preventing drunkenness in mice were tested,and a mouse model of alcoholic liver injury was established to detect its relevant indicators of alcoholic liver injury and evaluate its protective effect on alcoholic liver injury in mice.Compared with the blank group,there was no significant difference in the duration of drunkenness in mice,but the latency of drunkenness in mice was significantly prolonged(P<0.05),indicating that it has a certain anti drunkenness effect.Compared with the model group,the high,medium,and low-dose groups significantly reduced the levels of MDA and TG,and significantly increased the levels of GSH;The pathological changes in liver tissue were also alleviated to varying degrees in each dose group,with the low-dose group showing the most significant changes.Therefore,the test substance has a certain anti drunkenness effect and a certain protective effect on alcoholic liver injury.

关 键 词：肝损伤 解酒 防醉 保肝 

分 类 号：R285.5[医药卫生—中药学]