宫颈高级别鳞状上皮内瘤变患者冷刀宫颈锥切术后发生高危型人乳头瘤病毒持续感染的影响因素  

Influencing factors of high-risk human papillomavirus persistent infection after cold knife conization in patients with cervical high-grade squamous intraepithelial neoplasia

作　　者：龙起珏[1] 蔡健[1] 石日玲 林琳 LONG Qijue;CAI Jian;SHI Riling;LIN Lin(Department of Gynecology of Beihai People’s Hospital,Beihai 536000 Guangxi,China)

机构地区：[1]北海市人民医院妇科,广西北海536000

出　　处：《中国民康医学》2025年第6期12-15,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析宫颈高级别鳞状上皮内瘤变(HSIL)患者冷刀宫颈锥切术后发生高危型人乳头瘤病毒(HR-HPV)持续感染的影响因素。方法:回顾性分析2019年8月至2022年8月该院收治的234例行冷刀宫颈锥切术的HSIL患者的临床资料,统计HSIL患者冷刀宫颈锥切术后HR-HPV持续感染发生情况,采用Logistic回归分析HSIL患者冷刀宫颈锥切术后发生HR-HPV持续感染的影响因素。结果:234例HSIL患者冷刀宫颈锥切术后发生HR-HPV持续感染38例,发生率为16.24%(38/234),设为感染组,其余设为非感染组;感染组未绝经、HPV高危感染类型数>1种、术前HPV高负荷量、术后切缘阳性、人工流产≥2次、术后未接种HPV疫苗等占比均高于非感染组,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,未绝经、HPV高危感染类型数>1种、术前HPV高负荷量、术后切缘阳性、人工流产≥2次、术后未接种HPV疫苗等均为影响HSIL患者冷刀宫颈锥切术后发生HR-HPV持续感染的危险因素(OR>1,P<0.05)。结论:未绝经、HPV高危感染类型数>1种、术前HPV高负荷量、术后切缘阳性、人工流产≥2次、术后未接种HPV疫苗等均为影响HSIL患者冷刀宫颈锥切术后发生HR-HPV持续感染的危险因素。Objective:To analyze influencing factors of persistent infection of high-risk human papillomavirus(HR-HPV)in patients with cervical high-grade squamous intraepithelial neoplasia(HSIL)after cold knife conization.Methods:The clinical data of 234 patients with HSIL who underwent cold knife conization in the hospital from August 2019 to August 2022 were retrospectively analyzed.The incidence of HR-HPV persistent infection after cold knife cervical conization in the HSIL patients was statistically analyzed.Logistic regression was used to analyze the influencing factors of HR-HPV persistent infection after cold knife conization in the HSIL patients.Results:38 cases of HR-HPV persistent infection occurred in the 234 patients with HSIL after cold knife conization,the incidence rate was 16.24%(38/234),which was set as the infection group,and the rest were set as the non-infection group.The proportions of non-menopause women,number of high-risk HPV infection types>1,high preoperative HPV load,positive postoperative margin,induced abortion≥2 times,and no HPV vaccine after surgery in the infection group were higher than those in the non-infection group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that non-menopause,number of high-risk HPV infection types>1,high preoperative HPV load,positive postoperative margin,induced abortion≥2 times,and no HPV vaccination after surgery were all risk factors for HR-HPV persistent infection in the HSIL patients after cold knife conization(OR>1,P<0.05).Conclusions:Non-menopause,number of high-risk HPV infection types>1,high preoperative HPV load,positive postoperative margin,induced abortion≥2 times,and no HPV vaccination after surgery were the risk factors for HR-HPV persistent infection in the HSIL patients after cold knife conization.

关 键 词：宫颈高级别鳞状上皮内瘤变 冷刀锥切术 高危型人乳头状瘤病毒 持续感染 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]