醒脑静联合丙戊酸钠治疗卒中后继发性癫痫患者的效果  

Effects of Xingnaojing combined with Sodium valproate in treatment of patients with secondary epilepsy after stroke

作　　者：王欣 WANG Xin(1^(st)Ward of Department of Neurology of Xihua County People’s Hospital,Zhoukou 466600 Henan,China)

机构地区：[1]西华县人民医院神经内科一病区,河南周口466600

出　　处：《中国民康医学》2025年第6期71-73,85,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察醒脑静联合丙戊酸钠治疗卒中后继发性癫痫患者的效果。方法:选取2021年1月至2023年1月该院收治的84例卒中后继发性癫痫患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各42例。两组均给予常规治疗,在此基础上,对照组给予丙戊酸钠治疗,观察组在对照组基础上联合醒脑静治疗,两组均持续治疗2个月。比较两组临床疗效,治疗前后癫痫发作情况(发作次数、发作持续时间)、血清学指标[神经元特异性烯醇化酶(NSE)、细胞间黏附分子-1(ICAM-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.24%(40/42),高于对照组的78.57%(33/42),差异有统计学意义(P<0.05);治疗后,两组癫痫发作次数均少于治疗前,且观察组少于对照组,两组癫痫发作持续时间均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05);治疗后,两组NSE、ICAM-1、IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:醒脑静联合丙戊酸钠治疗卒中后继发性癫痫患者可提高治疗总有效率,改善癫痫发作情况,降低血清学指标水平,效果优于单纯丙戊酸钠治疗。Objective:To observe effects of Xingnaojing combined with Sodium valproate in treatment of patients with secondary epilepsy after stroke.Methods:A prospective study was conducted on 84 patients with secondary epilepsy after stroke admitted to this hospital from January 2021 to January 2023.According to the random number table method,they were divided into control group and observation group,42 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Sodium valproate,while the observation group was treated with Xingnaojing on the basis of that of the control group.Both groups were treated for 2 months.The clinical efficacies,the seizures(number of seizures,duration of seizures),the serological indexes[neuron-specific enolase(NSE),intercellular adhesion molecule-1(ICAM-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.24%(40/42),which was higher than 78.57%(33/42)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the number of seizures in the two groups was less than that before the treatment,and that in the observation group was less than that in the control group;the duration of seizures in the two groups was shorter than that before the treatment,and that in the observation group was shorter than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of NSE,ICAM-1,IL-6 and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xingnaojing combined with Sodium valproate in the treatment of the patients with s

关 键 词：卒中 继发性癫痫 醒脑静 丙戊酸钠 不良反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]