血塞通联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果  

Effects of Xuesaitong combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction

作　　者：郭莉 GUO Li(Department of Neurology of Xinyang People’s Hospital,Xinyang 464000 Henan,China)

机构地区：[1]信阳市人民医院神经内科,河南信阳464000

出　　处：《中国民康医学》2025年第6期74-77,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血塞通联合阿替普酶静脉溶栓治疗急性脑梗死(ACI)患者的效果。方法:回顾性分析2021年12月至2024年1月该院收治的106例ACI患者的临床资料,按照治疗方法不同将其分为对照组和观察组各53例。两组均进行常规治疗,在此基础上,对照组给予阿替普酶静脉溶栓治疗,观察组在对照组基础上联合血塞通治疗,两组均持续治疗10 d。比较两组临床疗效,治疗前后中医证候积分、认知功能[简易智力状态检查量表(MMSE)]评分、日常生活能力[Barthel指数(BI)]评分、炎性指标[血清淀粉样蛋白A(SAA)、脂蛋白相关磷脂酶A2(Lp-PLA2)、肿瘤坏死因子-α(TNF-α)、可溶性CD40配体(sCD40L)]水平,以及不良反应发生率。结果:观察组治疗总有效率为90.57%(48/53),高于对照组的75.47%(40/53),差异有统计学意义(P<0.05);治疗后,两组感觉减退、语言謇涩、口舌歪斜、半身不遂、气短乏力、面色㿠白、自汗出等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组MMSE、BI评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组SAA、Lp-PLA2、TNF-α、sCD40L水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血塞通联合阿替普酶静脉溶栓治疗ACI患者可提高治疗总有效率和认知功能、日常生活能力评分,降低中医证候积分和炎性指标水平,效果优于单纯阿替普酶静脉溶栓治疗。Objective:To observe effects of Xuesaitong combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction(ACI).Methods:The clinical data of 106 patients with ACI admitted to this hospital from December 2021 to January 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,53 cases in each group.Both groups received routine treatment.On this basis,the control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Xuesaitong on the basis of that of the control group.Both groups were treated for 10 d.The clinical efficacies,the TCM syndrome scores,the cognitive function[mini-mental state examination(MMSE)]scores,the activities of daily living[Barthel index(BI)]scores,the inflammatory indexes[serum amyloid A(SAA),lipoprotein-associated phospholipase A2(Lp-PLA2),tumor necrosis factor-α(TNF-α),soluble CD40 ligand(sCD40L)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.57%(48/53),which was higher than 75.47%(40/53)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as hypoesthesia,language astringency,wry tongue,hemiplegia,shortness of breath,fatigue,complexion,spontaneous sweating in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of MMSE and BI in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of SAA,Lp-PLA2,TNF-αand sCD40 L in the two groups were lower than those before the treatment,those in the

关 键 词：急性脑梗死 血塞通 阿替普酶 中医证候积分 认知功能 日常生活能力 炎性指标 

分 类 号：R743.33[医药卫生—神经病学与精神病学]