疏肝和胃汤加减联合四联疗法治疗慢性胃溃疡患者的效果  

Effects of Shugan Hewei decoction combined with quadruple therapy in treatment of patients with chronic gastric ulcer

作　　者：贾佳 王帅 安俊丽 JIA Jia;WANG Shuai;AN Junli(Luohe Sixth People’s Hospital,Outpatient Pharmacy,Luohe 462000 Henan,China;Luohe Sixth People’s Hospital,Gastroenterology Department,Luohe 462000 Henan,China)

机构地区：[1]漯河市第六人民医院门诊药房,河南漯河462000 [2]漯河市第六人民医院消化内科,河南漯河462000

出　　处：《中国民康医学》2025年第6期107-110,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察疏肝和胃汤加减联合四联疗法治疗慢性胃溃疡(GU)患者的效果。方法:回顾性分析2022年1月至2023年1月该院收治的78例慢性GU患者的临床资料,按照治疗方案不同将其分为对照组与观察组各39例。对照组采用四联疗法治疗,观察组在对照组基础上联合疏肝和胃汤加减治疗。比较两组临床疗效,幽门螺旋杆菌(Hp)清除率,治疗前后中医证候积分(胃脘胀痛、嗳气反酸、善太息、胸闷乏力)、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、胃肠激素指标[三叶因子2(TFF2)、胃泌素]水平,以及治疗期间不良反应发生率、复发率。结果:观察组治疗总有效率为97.44%(38/39),高于对照组的79.49%(31/39),差异有统计学意义(P<0.05);观察组Hp清除率高于对照组,差异有统计学意义(P<0.05);治疗后,两组胃脘胀痛、嗳气反酸、善太息、胸闷乏力等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α、胃泌素水平均低于治疗前,且观察组低于对照组,两组TFF2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:疏肝和胃汤加减联合四联疗法治疗慢性GU可提高治疗总有效率和Hp清除率,改善胃肠激素指标水平,以及降低炎性因子水平、中医证候积分和复发率,效果优于单纯四联疗法治疗。Objective:To observe effects of Shugan Hewei decoction combined with quadruple therapy in treatment of patients with chronic gastric ulcer(GU).Methods:The clinical data of 78 patients with chronic GU admitted to this hospital from January 2022 to January 2023 were retrospectively analyzed.According to different treatment plans,they were divided into control group and observation group,39 cases in each group.The control group was treated with quadruple therapy,while the observation group was treated with Shugan Hewei decoction on the basis of that of the control group.The clinical efficacy,the Hp clearance rate,the TCM syndrome scores(epigastric pain,belching and acid reflux,sighing,chest tightness and fatigue),the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels and the gastrointestinal hormone indicators[trefoil factor 2(TFF2),gastrin]levels before and after the treatment,the incidence of adverse reactions,and the recurrence rate during the treatment were compared between the two groups.Results:The total effective rate of the observation group was 97.44%(38/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).The Hp clearance rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as epigastric pain,belching and acid reflux,sighing,chest tightness and fatigue in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand gastrin in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of TFF2 in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control grou

关 键 词：疏肝和胃汤 四联疗法 慢性胃溃疡 炎性因子 胃肠激素 复发率 

分 类 号：R573.1[医药卫生—消化系统]