尿IGFBP7、TIMP-2、肾小管损伤标志物水平联合检测在失代偿期乙肝肝硬化合并肾损伤患者中的诊断效能  

Diagnostic efficiency of combined detection of urinary IGFBP7,TIMP-2 and renal tubular injury markers in patients with decompensated hepatitis B cirrhosis complicated with kidney injury

作　　者：苏菡 袁珊 SU Han;YUAN Shan(Department of Clinical Laboratory of Nanyang First People’s Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市第一人民医院检验科,河南南阳473000

出　　处：《中国民康医学》2025年第6期119-121,125,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析尿胰岛素样生长因子结合蛋白7(IGFBP7)、基质金属蛋白酶组织抑制因子-2(TIMP-2)、肾小管损伤标志物[视黄醇结合蛋白(RBP)、β_(2)-微球蛋白(β_(2)-MG)、α_(1)-微球蛋白(α_(1)-MG)]水平联合检测在失代偿期乙型病毒性肝炎(乙肝)肝硬化合并肾损伤(KI)患者中的诊断效能。方法:选取2021年1月至2023年2月该院收治的108例失代偿期乙肝肝硬化患者为观察组,另选取同期该院54名健康体检者为对照组,根据失代偿期乙肝肝硬化患者是否发生KI将其分为发生KI组(n=35)和未发生KI组(n=73)。比较两组及发生KI组与未发生KI组尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平;分析尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平单项及联合检测在失代偿期乙肝肝硬化合并KI诊断中的效能。结果:观察组尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平均高于对照组,差异有统计学意义(P<0.05);发生KI组尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平均高于未发生KI组,差异有统计学意义(P<0.05);受试者工作特征曲线分析结果显示,尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平单项及联合检测诊断失代偿期乙肝肝硬化患者合并KI的曲线下面积分别为0.881、0.875、0.847、0.789、0.867、0.964,联合检测诊断效能高于单项检测。结论:尿IGFBP7、TIMP-2、RBP、β_(2)-MG、α_(1)-MG水平联合检测在失代偿期乙肝肝硬化合并KI患者中的诊断效能高于单项检测。Objective:To analyze diagnostic efficiency of combined detection of urinary insulin-like growth factor binding protein 7(IGFBP7),tissue inhibitor of matrix metalloproteinase-2(TIMP-2)and renal tubular injury markers[retinol-binding protein(RBP),β_(2)-microglobulin(β_(2)-MG),α_(1)-microglobulin(α_(1)-MG)]in patients with decompensated hepatitis B cirrhosis complicated with kidney injury(KI).Methods:A total of 108 patients with decompensated hepatitis B cirrhosis admitted to this hospital from January 2021 to February 2023 were selected as the observation group,and 54 healthy subjects during the same period were selected as the control group.According to whether KI occurred in the patients with decompensated hepatitis B cirrhosis,they were divided into KI group(n=35)and non-KI group(n=73).The levels of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)-MG were compared between the two groups and the KI group and the non-KI group.The efficiency of single and combined detection of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)-MG levels in the diagnosis of decompensated hepatitis B cirrhosis complicated with KI were analyzed.Results:The levels of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)-MG in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)-MG in the KI group were higher than those in the non-KI group,and the differences were statistically significant(P<0.05).The receiver operating characteristic curve analysis showed that the area under the curve of single and combined detection of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)-MG levels in the diagnosis of KI in the patients complicated with decompensated hepatitis B cirrhosis were 0.881,0.875,0.847,0.789,0.867 and 0.964,separately;and the diagnostic efficiency of combined detection was higher than that of single detection.Conclusions:The diagnostic efficiency of combined detection of urinary IGFBP7,TIMP-2,RBP,β_(2)-MG andα_(1)

关 键 词：胰岛素样生长因子结合蛋白7 基质金属蛋白酶组织抑制因子-2 视黄醇结合蛋白 β_(2)-微球蛋白 α_(1)-微球蛋白 乙肝肝硬化 肾损伤 

分 类 号：R575.2[医药卫生—消化系统]