错配修复蛋白表达缺陷与胃腺癌临床病理特征的相关性  

Correlation between mismatch repair protein expression defects and clinicopathological features of gastric adenocarcinoma

作　　者：徐丽艳[1] 陈艳[1] 周智俊[1] 葛玲[1] 郑新春 许晓其 XU Liyan;CHEN Yan;ZHOU Zhijun;GE Ling;ZHENG Xinchun;XU Xiaoqi(Department of Pathology of the Third Hospital of Xiamen,Xiamen 361100 Fujian,China)

机构地区：[1]厦门市第三医院病理科,福建厦门361100

出　　处：《中国民康医学》2025年第6期126-128,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析错配修复蛋白表达缺陷(dMMR)与胃腺癌临床病理特征的相关性。方法:回顾性分析2020—2023年该院收治的100例胃腺癌患者的临床资料,采集胃腺癌组织标本,根据错配修复(MMR)蛋白表达缺失情况,将其纳入MMR蛋白表达正常(pMMR)组与dMMR组,分析dMMR与胃腺癌临床病理特征的相关性。结果:100例胃腺癌患者中,dMMR 33例,占比33.00%,其中MutL同源物1缺失22例、减数分裂后分离蛋白2缺失11例,未见mut S同种组织蛋白2、mut S同种组织蛋白6缺失;两组肿瘤远处转移、肿瘤最大直径、临床分期比较,差异均无统计学意义(P>0.05);dMMR组肿瘤分化程度为低分化、有淋巴结转移、肿瘤浸润程度T3~T4占比均高于pMMR组,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,dMMR与胃腺癌肿瘤分化程度、肿瘤浸润程度、淋巴结转移等临床病理特征均呈正相关(r>0,P<0.05)。结论:dMMR与胃腺癌肿瘤分化程度、肿瘤浸润程度、淋巴结转移等临床病理特征均呈正相关。Objective:To analyze correlation between mismatch repair deficient(dMMR)and clinicopathological features of gastric adenocarcinoma.Methods:The clinical data of 100 patients with gastric adenocarcinoma admitted to the hospital from 2020 to 2023 were retrospectively analyzed.The gastric adenocarcinoma tissue samples were collected.According to the loss of mismatch repair(MMR)protein expression,these patients were divided into the normal MMR protein expression(pMMR)group and the dMMR group.The correlation between dMMR and the clinicopathological features of gastric adenocarcinoma was analyzed.Results:Of the 100 gastric adenocarcinoma patients,there were 33 cases of dMMR,accounting for 33.00%.MutL homolog 1 deletion was found in 22 cases,postmeiotic separation protein 2 deletion wan seen in 11 cases,and mut S homologous tissue protein 2 and mut S homologous tissue protein 6 deletion were not found.There were no significant differences in distant metastasis,maximum tumor diameter and clinical stage between the two groups(P>0.05).The proportions of poorly differentiated tumors,lymph node metastasis,and tumor infiltration T3-T4 in the dMMR group were higher than those in the pMMR group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that dMMR was positively correlated with the clinicopathological features such as tumor differentiation,tumor invasion and lymph node metastasis(r>0,P<0.05).Conclusions:dMMR is positively correlated with the clinicopathological features such as tumor differentiation,tumor invasion and lymph node metastasis of gastric adenocarcinoma.

关 键 词：错配修复蛋白表达缺陷 胃腺癌 临床病理特征 相关性 

分 类 号：R735.2[医药卫生—肿瘤]