血清GRP94、sTM、ADAM15水平与急性肺栓塞患者病情程度的相关性分析及对预后的预测价值  

Correlation analysis of serum GRP94,sTM and ADAM5 levels with disease severity in patients with acute pulmonary embolism and their predictive value for prognosis

作　　者：庞楠 董丽敏 张卫云 PANG Nan;DONG Limin;ZHANG Weiyun(Department of Clinical Laboratory,Zhoukou Maternal and Child Health Hospital(Children's Hospital),Zhoukou 466000,China)

机构地区：[1]周口市妇幼保健院(市儿童医院)检验科,河南周口466000

出　　处：《黑龙江医药科学》2025年第3期80-83,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关计划联合共建项目,编号:LHGJ20201016。

摘　　要：目的:分析急性肺栓塞患者血清葡萄糖调节蛋白94(GRP94)、可溶性血栓调节蛋白(sTM)、解整合素金属蛋白酶15(ADAM15)水平与急性肺栓塞患者病情程度的相关性及对临床预后的预测价值。方法:选取2021年7月至2023年8月周口市妇幼保健院(市儿童医院)急性肺栓塞患者74例为研究组(n=74),根据纳入比例另选取同期到院健康体检者74例为对照组(n=74)。根据患者病情程度分为重度阻塞、中度阻塞、轻度阻塞;根据不同预后分为预后良好组与预后不良患者。对比两组及不同病情程度入院时血清GRP94、sTM、ADAM15水平,并分析其相关性;对比不同预后患者入院时血清各指标水平,探讨其联合检测对患者预后的预测价值。结果:研究组入院时血清GRP94、sTM、ADAM15水平显著高于对照组(P<0.05);重度阻塞血清GRP94、sTM、ADAM15水平显著高于中度阻塞及轻度阻塞,中度阻塞血清GRP94、sTM、ADAM15水平显著高于轻度阻塞(P<0.05);血清GRP94、sTM、ADAM15与病情程度均呈正相关(r=0.654、0.627、0.691,P<0.05);预后不良患者入院时GRP94、sTM、ADAM15水平显著高于预后良好患者(P<0.05);入院时血清GRP94、sTM、ADAM15水平联合预测预后不良的曲线下面积(AUC)为0.839,均高于各指标单独预测。结论:血清GRP94、sTM、ADAM15与急性肺栓塞病情程度相关,其联合检测对预测患者预后状况具有重要价值,为临床诊治提供可靠参考依据。Objective:To analyze the correlation between serum levels of glucose-regulated protein 94(GRP94),soluble thrombomodulin(sTM)and adisintegrin and metalloproteinase 15(ADAM15)in patients with acute pulmonary embolism(APE)and the severity of their condition,as well as the predictive value of these biomarkers for clinical prognosis.Methods:Patients with acute pulmonary embolism at Zhoukou Maternal and Child Health Hospital(City Children's Hospital)From July 2021 to August 2023 were selected as the study group(n=74).Healthy individuals who underwent physical examinations during the same period were selected as the control group(n=74),based on a matching ratio.The study group was further divided into severe,moderate and mild obstruction subgroups based on disease severity.Additionally,patients were classified into good prognosis and poor prognosis groups based on their outcomes.Serum levels of GRP94,sTM and ADAM15 were compared between the two groups and among different severity subgroups upon admission,and their correlations were analyzed.Serum levels of these biomarkers upon admission were also compared between patients with different prognoses to explore the predictive value of their combined detection for patient prognosis.Results:Upon admission,serum levels of GRP94,sTM and ADAM15 were significantly higher in the study group than in the control group(P<0.05).Levels of these biomarkers were significantly higher in patients with severe obstruction than in those with moderate and mild obstruction,and levels of these biomarkers in patients with moderate obstruction were significantly higher than in those with mild obstruction(P<0.05).Serum levels of GRP94,sTM and ADAM15 were positively correlated with disease severity(r=0.654,0.627,0.691;P<0.05).Patients with poor prognosis had significantly higher levels of GRP94,sTM and ADAM15 upon admission than those with good prognosis(P<0.05).The area under the curve(AUC)for the combined prediction of poor prognosis using serum levels of GRP94,sTM and ADAM15 upon admission was 0

关 键 词：GRP94 STM ADAM15 急性肺栓塞 病情 预后 

分 类 号：R446.1[医药卫生—诊断学]