钌(Ⅱ)多吡啶配合物纳米颗粒的组装及抗肿瘤活性研究  

Encapsulation of Ruthenium(Ⅱ)Polypyridine Complex Nanoparticles and Their Antitumor Activity

作　　者：崔英[1] 蔡自由[1] Cui Ying;Cai Ziyou(Guangdong Food and Drug Vocational College,Guangzhou 510520,China)

机构地区：[1]广东食品药品职业学院,广东广州510520

出　　处：《广东化工》2025年第3期66-68,共3页Guangdong Chemical Industry

基　　金：广东省中医药局中医药科研项目(20252028);广东食品药品职业学院自然科学基金项目(2024ZR10);广东食品药品职业学院“化学实验技术”技能大师工作室项目(2023JNDS01)。

摘　　要：钌配合物是一类非常有前景的抗肿瘤药物,Ru(Ⅱ)多吡啶配合物因其独特的光物理、光化学和生物学特性而备受关注。尽管它们有很好的治疗前景,但绝大多数化合物水溶性和癌症选择性较差。为了克服这些限制,许多研究工作都致力于将Ru(Ⅱ)多吡啶配合物物理封装成纳米颗粒制备成纳米药物。本文重点介绍了Ru(Ⅱ)多吡啶配合物纳米颗粒的设计、制备和在抗肿瘤治疗中的应用进展。Ruthenium complexes are a very promising class of antineoplastic drugs,and Ru(Ⅱ)polypyridine complexes have attracted much attention due to their unique photophysical,photochemical and biological properties.Although they have great therapeutic prospects,the vast majority of compounds are less water-soluble and cancer-selective.In order to overcome these limitations,many research efforts have been devoted to the physical encapsulation of Ru(Ⅱ)polypyridine complexes into nanoparticles to form nanomedicines.In this review,we focus on the design,preparation and application of Ru(Ⅱ)polypyridine complex nanoparticles in anti-tumor therapy.

关 键 词：钌配合物 纳米颗粒 抗肿瘤 

分 类 号：O633[理学—高分子化学]