阿尔茨海默病病人血清骨硬化蛋白、25羟维生素D水平与MMSE评分的相关性研究  

Correlation of serum levels of sclerostin and 25 hydroxyvitamin D with MMSE score in patients with Alzheimer’s disease

作　　者：荆超楠 张冠群 王江波 JING Chaonan;ZHANG Guanqun;WANG Jiangbo(Department of Neurology,Xuzhou Clinical College of Xuzhou Medical University(Xuzhou Central Hospital),Xuzhou 221009,China)

机构地区：[1]徐州医科大学徐州临床学院,徐州市中心医院神经内科,江苏省徐州市221009

出　　处：《实用老年医学》2025年第3期268-271,共4页Practical Geriatrics

基　　金：徐州市基础研究计划(KC22067);徐州市重点研发计划(社会发展)(KC21173);江苏省中医药科技发展计划(QN202115)。

摘　　要：目的探讨血清中骨硬化蛋白(sclerostin,SOST)、25羟维生素D[25(OH)D]水平与AD病人认知功能的相关性。方法选取2020-2022年在徐州市中心医院就诊的AD病人30例、轻度认知功能障碍(MCI)病人30例,以及同期年龄、性别、文化程度相匹配的健康对照30例为研究对象,检测并比较3组病人血清SOST、25(OH)D水平,分析AD病人血清SOST、25(OH)D水平与MMSE评分的相关性。结果AD组病人血清SOST水平显著高于健康对照组,血清25(OH)D水平低于健康对照组(P<0.01);MCI组血清SOST、25(OH)D水平与健康对照组相比,差异均无统计学意义(均P>0.05)。AD病人血清SOST水平与MMSE评分呈负相关(r=-0.875,P<0.05),25(OH)D水平与MMSE评分呈正相关(r=0.783,P<0.05);多元线性逐步回归分析结果显示,25(OH)D及血清SOST水平是AD病人MMSE评分的独立影响因素。结论血清SOST、25(OH)D水平与AD病人的认知功能损害密切相关,血清SOST和25(OH)D可能是AD的潜在治疗靶点。Objective To investigate the correlation of serum levels of sclerostin(SOST)and 25 hydroxyvitamin D[25(OH)D]with cognitive function in the patients with Alzheimer’s disease(AD).Methods A total of 30 patients with AD and 30 patients with mild cognitive impairment(MCI)treated in Xuzhou Central Hospital from January 2020 to December 2022,and 30 cases of age-,sex-and education-matched healthy controls during the same period were enrolled in this study.The serum levels of SOST and 25(OH)D in the three groups were detected and compared,and the correlation between serum levels of SOST,25(OH)D and the score of mini-mental state examination(MMSE)in AD group was analyzed.Results The serum SOST level was significantly higher,and the serum 25(OH)D level was significantly lower in AD group than that in healthy control group(P<0.01).There were no significant differences in serum SOST and 25(OH)D levels between MCI group and healthy control group(all P>0.05).Serum SOST level was negatively correlated with MMSE score(P<0.05),and 25(OH)D level was positively correlated with MMSE score in AD group(P<0.05).The results of multiple linear regression analysis showed that serum levels of 25(OH)D and SOST were the independent influencing factors of MMSE score in the AD patients.Conclusions Serum SOST level and 25(OH)D level are closely related to cognitive impairment in the AD patients,and can be potential therapeutic targets for AD.

关 键 词：骨硬化蛋白 25羟维生素D 阿尔茨海默病 简易智力状态检查量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]