银杏叶提取物注射液联合依达拉奉右莰醇治疗急性脑梗死的临床研究  

Clinical Study of Extract of Ginkgo Biloba Leaves Injection Combined with Edaravone and Dexborneol in Treatment of Acute Cerebral Infarction

作　　者：陈龙雯 刘丹 陈骏轩 CHEN Longwen;LIU Dan;CHEN Junxuan(Department of Neurology,Fengcheng People's Hospital,Fengcheng 331100,China)

机构地区：[1]丰城市人民医院神经内科,江西丰城331100 [2]南昌大学抚州医学院,江西抚州344000

出　　处：《中国医学创新》2025年第7期27-31,共5页Medical Innovation of China

摘　　要：目的:探讨银杏叶提取物注射液联合依达拉奉右莰醇用于急性脑梗死(ACI)治疗对患者血液流变学指标、神经功能的影响。方法:选取丰城市人民医院2022年5月—2024年2月收治的ACI患者84例,按随机数字表法分为对照组(42例,依达拉奉右莰醇治疗)、观察组(42例,依达拉奉右莰醇+银杏叶提取物注射液治疗)。对比两组临床疗效、血液流变学指标、神经功能及不良反应发生情况。结果:观察组临床总有效率(95.24%)较对照组(78.57%)高,差异有统计学意义(P<0.05)。两组治疗14 d后的血浆黏度(PV)、全血高切黏度(HBV)、全血低切黏度(LBV)、红细胞压积(HCT)、神经元特异性烯醇化酶(NSE)、S100钙结合蛋白β(S100β)及美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低,且观察组均低于对照组(P<0.05)。两组治疗14 d后的脑源性神经营养因子(BDNF)均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液和依达拉奉右莰醇联合用于ACI治疗效果显著,安全性良好。Objective:To investigate the effects of Extract of Ginkgo Biloba Leaves Injection combined with Edaravone and Dexborneol in the treatment of acute cerebral infarction(ACI)on hemorheology indexes and neurological function.Method:A total of 84 patients with ACI admitted to Fengcheng People's Hospital from May 2022 to February 2024 were selected and divided into a control group(42 cases,treated with Edaravone and Dexborneol)and an observation group(42 cases,treated with Edaravone and Dexborneol+Extract of Ginkgo Biloba Leaves Injection)according to random number table method.The clinical efficacy,hemorheology indexes,neurological function and adverse reactions were compared between the two groups.Result:The total clinical efficacy rate(95.24%)in the observation group was higher than that in the control group(78.57%),the difference was statistically significant(P<0.05).After 14 days of treatment,the plasma viscosity(PV),high blood viscosity(HBV),low blood viscosity(LBV),hematocrit(HCT),neuron specific enolase(NSE),S100 calcium binding protein beta(S100β),and national institutes of health stroke scale(NIHSS)scores in both groups decreased compared to before treatment,and those of the observation group were lower than those of the control group(P<0.05).After 14 days of treatment,the levels of brain-derived neurotrophic factor(BDNF)in both groups increased compared to before treatment,and the observation group was higher than that the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Extract of Ginkgo Biloba Leaves Injection and Edaravone and Dexborneol for the treatment of ACI has significant therapeutic effect and good safety.

关 键 词：急性脑梗死 银杏叶提取物注射液 依达拉奉右莰醇 血液流变学指标 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]