甲氧氯普胺联合托烷司琼对全身麻醉结直肠癌手术老年患者术后恶心呕吐的预防作用  

The Preventive Effect of Metoclopramide Combined with Tropisetron on Postoperative Nausea and Vomiting in Elderly Patients Undergoing Colorectal Cancer Surgery with General Anesthesia

作　　者：金运松 JIN Yunsong(Department of Anesthesiology,the Second People's Hospital of Dexing City,Dexing 334224,China)

机构地区：[1]德兴市第二人民医院麻醉科,江西德兴334224

出　　处：《中国医学创新》2025年第7期48-51,共4页Medical Innovation of China

摘　　要：目的:探究甲氧氯普胺和托烷司琼联合使用在预防全身麻醉结直肠癌手术老年患者术后恶心呕吐的效果及安全性。方法:选取德兴市第二人民医院于2021年2月—2024年1月行全身麻醉结直肠癌手术的101例老年患者作为前瞻性研究对象,按随机数字表法将其分为A组(n=50)和B组(n=51);A组给予甲氧氯普胺进行治疗,B组则采用甲氧氯普胺联合托烷司琼进行治疗,对比两组患者的生命体征、疼痛程度、恶心呕吐发生率、术后恢复情况及术后72 h内不良反应发生率。结果:两组术毕时平均动脉压(MAP)、心率(HR)及血氧饱和度(SpO_(2))对比,差异均无统计学意义(P>0.05);B组术后6、12 h的视觉模拟评分法(VAS)评分均低于A组(P<0.05);B组术后6、12、18 h的恶心、呕吐发生率均低于A组(P<0.05)。B组拔管时间、首次下床时间、首排气时间及住院时间均短于A组,且术后72 h内不良反应发生率低于A组(P<0.05)。结论:甲氧氯普胺联合托烷司琼能有效降低全身麻醉结直肠癌手术老年患者术后恶心呕吐的发生率,缩短恢复时间,减少术后72 h内不良反应发生。Objective:To explore the efficacy and safety of the combined use of Metoclopramide and Tropisetron in preventing postoperative nausea and vomiting in elderly patients undergoing colorectal cancer surgery under general anesthesia.Method:A total of 101 elderly patients who underwent general anesthesia for colorectal cancer surgery in the Second People's Hospital of Dexing City from February 2021 to January 2024 were selected for this prospective study.They were divided into group A(n=50)and group B(n=51)according to the random number table method.Group A received Metoclopramide treatment,while group B was treated with a combination of Metoclopramide and Tropisetron.The vital signs,pain levels,incidence of nausea and vomiting,postoperative recovery,and the incidence of adverse reactions within 72 hours postoperatively were compared between the two groups.Result:At the end of operation,there were no significant differences in mean arterial pressure(MAP),heart rate(HR),and blood oxygen saturation(SpO_(2))between the two groups(P>0.05).The visual analogue scale(VAS)scores of group B were lower than those of group A at 6 and 12 h after operation(P<0.05).The incidences of nausea and vomiting at 6,12 and 18 h after operation in group B were lower than those in group A(P<0.05).The time of tube removal,first time of getting out of bed,first exhaust time and hospital stay of group B were shorter than those of group A,and the incidence of adverse reactions within 72 h after operation was lower than that of group A(P<0.05).Conclusion:The combination of Metoclopramide and Tropisetron effectively reduces the incidence of postoperative nausea and vomiting,shortens recovery time,and reduce the occurrence of adverse reactions within 72 h after operation in elderly patients undergoing colorectal cancer surgery under general anesthesia.

关 键 词：甲氧氯普胺 托烷司琼 结直肠癌手术 老年患者 术后恶心呕吐 

分 类 号：R73[医药卫生—肿瘤]