精神分裂症患者血清IGF-2水平变化及其与临床特征的关系  

Changes of Serum IGF-2 Levels in Patients with Schizophrenia and Their Relationship with Clinical Features

作　　者：熊思敏 XIONG Simin(Department of Psychiatry,Jiangxi Mental Hospital,Nanchang 330000,China)

机构地区：[1]江西省精神病院精神科,江西南昌330000

出　　处：《中国医学创新》2025年第7期126-129,共4页Medical Innovation of China

摘　　要：目的:分析精神分裂症患者血清胰岛素样生长因子-2(IGF-2)水平变化及其与临床特征的关系。方法:选取江西省精神病院精神科2022年1月—2023年10月收治的40例精神分裂症患者为研究组,再选取40例健康体检者为对照组,根据研究组患者IGF-2平均数水平将其分为IGF-2高水平组(24例)、IGF-2低水平组(16例);比较研究组与对照组认知功能、IGF-2,比较IGF-2高水平组与低水平组精神症状、认知功能,分析IGF-2水平与精神分裂症患者精神症状、认知功能的相关性。结果:研究组连线测试A(TMTA)高于对照组,IGF-2水平、数字符号编码测试(DSCT)、持续操作测验(CPT)、Stroop色词测验(SCWT)的单词总数、颜色总数、色/词总数均低于对照组,差异均有统计学意义(P<0.05);低水平组阳性与阴性症状量表(PANSS)阳性症状评分、阴性症状评分、总分、一般精神病理评分、TMTA均高于高水平组,DSCT、CPT、SCWT的单词总数、颜色总数、色/词总数均低于高水平组,差异均有统计学意义(P<0.05);Pearson相关分析显示,IGF-2水平与阴性症状评分呈负相关(r=-0.351,P=0.013);IGF-2水平与DSCT、TMTA无显著相关性(P>0.05),IGF-2水平与CPT及SCWT的单词总数、颜色总数、色/词总数均呈正相关(r=0.361、0.306、0.324、0.339,P=0.008、0.029、0.027、0.015)。结论:精神分裂症患者血清IGF-2水平与PANSS阴性症状、CPT及SCWT的单词总数、颜色总数、色/词总数具有较高的相关性。Objective:To analyze the changes of serum insulin-like growth factor-2(IGF-2)levels in patients with schizophrenia and its relationship with clinical features.Method:A total of 40 patients with schizophrenia admitted to the Psychiatric Department of Jiangxi Mental Hospital from January 2022 to October 2023 were selected as the study group,and 40 patients who underwent medical examination were selected as the control group.According to the average level of IGF-2,the patients in the study group were divided into a high level of IGF2 group(24 cases)and a low level of IGF-2 group(16 cases).The cognitive function and IGF-2 of the study group and the control group were compared,and the mental symptoms and cognitive function of the high level IGF-2 group and the low level IGF-2 group were compared,and the correlation between IGF-2 level and the mental symptoms and cognitive function of schizophrenia patients was analyzed.Result:Trail making test A(TMTA)in study group was higher than that in control group,IGF-2 level,digit symbol coding test(DSCT),continuous performance test(CPT),total number of words,total number of colors,total number of colors/words in the Stroop color word test(SCWT)were lower than those in control group(P<0.05).Positive symptom score,negative symptom score,total score,general psychopathological score of positive and negative syndrome scale(PANSS)and TMTA in low level group were higher than those in high level group,while DSCT,CPT,total number of words,total number of colors and total number of colors/words of SCWT in low level group were lower than those in high level group(P<0.05).Pearson correlation analysis showed that IGF-2 level was negatively correlated with negative symptom score(r=-0.351,P=0.013).There was no significant correlation between IGF-2 level and DSCT and TMTA(P>0.05),but IGF-2 level was positively correlated with CPT and total number of words,total number of colors,and total number of colors/words in SCWT(r=0.361,0.306,0.324,0.339,P=0.008,0.029,0.027,0.015).Conclusion:Serum IGF-2

关 键 词：精神分裂症 胰岛素样生长因子-2 临床特征 

分 类 号：R749.3[医药卫生—神经病学与精神病学]