草酸艾司西酞普兰联合喹硫平治疗对双相情感障碍抑郁发作患者HAMD、BRMS、SDSS评分及神经递质的影响  

Effects of Combined Treatment with Escitalopram Oxalate and Quetiapine on HAMD Scores,BRMS Scores,SDSS Scores and Neurotransmitters in Patients with Bipolar Disorder and Depressive Episodes

作　　者：李伟 LI Wei(Department of Psychiatry,the Third People's Hospital of Ji’an,Ji’an 343000,China)

机构地区：[1]吉安市第三人民医院精神科,江西吉安343000

出　　处：《中国医学创新》2025年第7期142-146,共5页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202240980)。

摘　　要：目的:观察在喹硫平治疗双相情感障碍(bipolar disorder,BPD)抑郁发作患者的基础上联合使用草酸艾司西酞对汉密尔顿抑郁量表(HAMD)、Bech-Rafaelsen狂躁量表(BRMS)、社会功能缺陷量表(SDSS)评分及神经递质的影响。方法:筛选2023年4月—2024年4月于吉安市第三人民医院就诊的BPD抑郁发作患者86例,使用随机编号法将患者等比例分为单药组与联合组,每组43例。单药组治疗口服喹硫平片,联合组在单药组治疗基础上,口服草酸艾司西酞普兰,对两组进行为期2个月的治疗并跟踪记录。观察两组患者的疗效以及HAMD、BRMS、SDSS评分及神经递质变化。结果:联合组治疗总有效率高于单药组(P<0.05);治疗后两组HAMD、BRMS、SDSS评分均低于治疗前,且联合组低于单药组(P<0.05);治疗后两组多巴胺(dopamine,DA)和5-羟色胺(5-hydroxytryptamine,5-HT)水平均较治疗前升高,且联合组均高于单药组(P<0.05);联合组不良反应发生率较单药组高,但差异无统计学意义(P>0.05)。结论:草酸艾司西酞普兰联合喹硫平治疗与单独使用喹硫平治疗相比能有效改善BPD抑郁发作患者抑郁症状,减缓转躁速度,调节神经递质,提高临床疗效。Objective:To observe the effect of combined treatment with Escitalopram Oxalate and Quetiapine on the Hamilton depression scale(HAMD)scores,Bech-Rafaelsen mania rating scale(BRMS)scores,social disability screening schedule(SDSS)scores and neurotransmitters in patients with bipolar disorder(BPD)and depressive episodes.Method:Eighty-six patients with BPD and depressive episodes who were treated at the Third People's Hospital of Ji’an from April 2023 to April 2024 were selected.The patients were equally divided into monotherapy group and combination group by random numbering method,with 43 cases in each group.The monotherapy group was treated with oral Quetiapine Tablets.On this basis,the combination group was treated with oral Escitalopram Oxalate.All patients were treated for 2 months and followed up.Therapeutic effects and changes in HAMD scores,BRMS scores,SDSS scores and neurotransmitters in the two groups were observed.Result:After treatment,the total effective rate of the combination group was higher than that of the monotherapy group(P<0.05).After treatment,HAMD,BRMS and SDSS scores of the two groups were lower than those before treatment,and those of the combination group were lower than those of the monotherapy group(P<0.05).After treatment,the levels of dopamine(DA)and 5-hydroxytryptamine(5-HT)in both groups were higher than those before treatment,and those in the combination group were higher than those in the monotherapy group(P<0.05).The incidence of adverse reactions in combination group was higher than that in monotherapy group,but the difference was not statistically significant(P>0.05).Conclusion:The combined treatment with Escitalopram Oxalate and Quetiapine can effectively improve depressive symptoms,reduce the risk of turning to mania,regulate neurotransmitters,and improve clinical efficacy in patients with BPD and depressive episodes.

关 键 词：双相情感障碍 抑郁发作 草酸艾司西酞普兰 喹硫平 神经递质 

分 类 号：R74[医药卫生—神经病学与精神病学]