子宫内膜癌与代谢综合征相关性研究进展  

Analysis of Studies on the Correlation between Endometrial Cancer and Metabolic Syndrome

作　　者：苏比努尔·沙达尔丁 韩莉莉[2] Subinuer Shadaerding;HAN Lili(Graduate School of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学研究生学院,新疆乌鲁木齐830054 [2]新疆维吾尔自治区人民医院妇科诊疗中心,新疆乌鲁木齐830002

出　　处：《中国医学创新》2025年第7期164-169,共6页Medical Innovation of China

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01C596);国家自然科学基金项目(82060166)。

摘　　要：子宫内膜癌(endometrial cancer,EC)是源于子宫内膜的上皮性恶性肿瘤,是妇科肿瘤最常见的三大恶性生殖系统肿瘤之一。代谢综合征(metabolic syndrome,MS)是多种代谢异常在个体集结的一种状态。这些代谢异常增加了心、肾、脑血管疾病的发生率,主要表现为中心性肥胖、血脂异常、高血糖、高血压等。目前认为MS与EC的病因息息相关,其中胰岛素抵抗及脂代谢紊乱的相关性分子机制研究引起了人们的广泛关注。MS不仅仅是EC的潜在危险因素,而且在诊疗EC过程提供重要的线索。本文通过深入探讨关于MS中关键分子通路进行展开,进一步叙述子宫内膜癌发生发展做一综述,旨在为子宫内膜癌的早期筛查、预防以诊治提供新的靶点及科学依据。Endometrial cancer(EC)is an epithelial malignancy originating from the endometrium,and is one of the three most common malignant reproductive system tumors in gynecologic oncology.Metabolic syndrome is a state in which multiple metabolic abnormalities cluster in an individual.These metabolic abnormalities increase the incidence of cardiac,renal,and cerebrovascular diseases mainly manifested as central obesity,dyslipidemia,hyperglycemia,and hypertension.MS is now recognized to contribute to the etiology of EC,and the molecular mechanisms underlying insulin resistance and lipid metabolism disorders have attracted much attention.MS is not only a potential risk factor for EC,but also provides important clues in the diagnosis and treatment of EC.In this article,we review the key molecular pathways involved in MS and further describe the development of endometrial cancer,with the aim of providing new targets and scientific evidence for early screening,prevention and diagnosis of endometrial cancer.

关 键 词：子宫内膜癌 代谢综合征 脂联素 瘦素 

分 类 号：R73[医药卫生—肿瘤]