血清CTRP3、YKL-40对口腔种植修复术患者种植体预后的预测价值  

The predictive value of serum CTRP3 and YKL-40 for implant prognosis in patients undergoing oral implant restoration

作　　者：仲崇文 唐德争[2] ZHONG Chongwen;TANG Dezheng(Department of Implantology,Chongwen Hospital of Stomatology,Dongcheng District,Beijing 100062,China;Department of Implantology,Beijing Stomatological Hospital,Capital Medical University)

机构地区：[1]北京市东城区崇文口腔医院种植科,100062 [2]首都医科大学附属北京口腔医院种植科

出　　处：《天津医药》2025年第3期292-296,共5页Tianjin Medical Journal

摘　　要：目的探讨血清补体C1q肿瘤坏死因子相关蛋白3(CTRP3)、甲壳质酶蛋白-40(YKL-40)对牙列缺损患者进行种植修复术后种植体预后的预测价值。方法选取牙列缺损患者98例为观察组,同期健康体检者98例为对照组;牙列缺损患者依据种植体预后分为预后良好组67例和预后不良组31例。采用酶联免疫吸附试验检测血清CTRP3、YKL-40水平;多因素Logistic回归分析种植体不良预后的影响因素;受试者工作特征(ROC)曲线评估血清CTRP3、YKL-40水平对种植体预后不良的预测价值。结果与对照组相比,观察组血清CTRP3水平降低,YKL-40水平升高(P<0.05);与预后良好组相比,预后不良组吸烟史比例和血清YKL-40水平升高,血清CTRP3水平降低(P<0.05);血清YKL-40水平升高、有吸烟史是影响患者种植体预后不良的危险因素,血清CTRP3水平升高是其保护因素(P<0.05);ROC曲线分析结果显示,联合血清CTRP3、YKL-40水平预测牙列缺损患者种植体不良预后的预测效能优于单一指标。结论牙列缺损患者血清CTRP3水平降低,YKL-40水平升高,二者均是影响种植体预后不良的潜在因素,且二者联合在预测牙列缺损患者种植体预后方面效能较高。Objective To investigate the predictive value of serum complement C1q tumor necrosis factor-related protein 3(CTRP3)and chitinase protein-40(YKL-40)in the prognosis of implants in patients with dentition defect after implant restoration.Methods A total of 98 patients with dentition defect were selected as the observation group,and 98 healthy people were selected as the control group.Based on the prognosis of the implant,patients were assigned into the good prognosis group(67 cases)and the poor prognosis group(31 cases).Enzyme linked immunosorbent assay was applied to detect serum levels of CTRP3 and YKL-40.Multivariate Logistic regression analysis was performed to analyze factors influencing the prognosis of implant defects.The receiver operating characteristic(ROC)curve was used to evaluate the efficacy of serum CTRP3 and YKL-40 levels in predicting implant prognosis.Results Compared with the control group,the serum CTRP3 level was prominently lower in the study group,and the serum YKL-40 level was prominently higher(P<0.05).Compared with the good prognosis group,the proportion of smoking patients and the serum YKL-40 level were prominently higher in the poor prognosis group,and the serum CTRP3 level was prominently lower(P<0.05).Elevated serum YKL-40 level and smoking history were risk factors for poor implant prognosis in patients,while elevated serum CTRP3 level was the protective factor(P<0.05).ROC curve analysis showed that the combination of serum CTRP3 and YKL-40 levels was superior to any single indicator in predicting the poor prognosis of implants in patients with dentition defect.Conclusion Serum CTRP3 level is decreased and serum YKL-40 level is increased in patients with dental defect,both of which are potential factors affecting poor implant prognosis.The combination of the two is more effective in predicting implant prognosis in patients with dental defect.

关 键 词：牙种植体 补体C1q肿瘤坏死因子相关蛋白3 甲壳质酶蛋白-40 牙列缺损 口腔种植修复术 预后 

分 类 号：R783.4[医药卫生—口腔医学]