间充质干细胞治疗急性胰腺炎的机制及研究进展  

Mechanism and research progress of mesenchymal stem cell therapy for acute pancreatitis

作　　者：范慧娟 刘涛涛 李楠 夏时海 FAN Huijuan;LIU Taotao;LI Nan;XIA Shihai(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Gastroenterology(Institute of Digestive diseases),Characteristic Medical Center of the Chinese People's Armed Police Force,Tianjin Key Laboratory of Hepatopancreatic Fiberosis and Molecular Diagnosis&Treatment)

机构地区：[1]天津中医药大学研究生院,301617 [2]中国人民武装警察部队特色医学中心消化内科(消化疾病研究所),天津市肝脏胰腺纤维化与分子诊疗重点实验室

出　　处：《天津医药》2025年第3期331-336,共6页Tianjin Medical Journal

基　　金：天津市卫生健康科技项目(TJWJ2023QN100)。

摘　　要：急性胰腺炎(AP)是一种自身消化性疾病,且可伴随全身炎症反应及多器官功能衰竭。间充质干细胞(MSCs)已用于AP治疗中并展现出良好的应用潜力,其可通过归巢至损伤部位、抗炎及免疫调节、抗氧化应激、抗凋亡及抗自噬等机制,有效减轻胰腺炎症并促进组织修复。此外,MSCs还可改善AP引起的肺、肠及心脏等多器官损伤。MSCs治疗AP的研究仍停留在动物实验阶段,临床研究较少。该文综述了MSCs治疗AP的相关机制及研究进展,以为其基础研究及临床应用提供参考。Acute pancreatitis(AP)is an autopeptic disease,which can be accompanied by systemic inflammation and multiple organ failure.Mesenchymal stem cells(MSCs)have been used in the treatment of AP and have shown good application potential.MSCs can act through multiple mechanisms to reduce pancreatic inflammation and enhance tissue repair.These mechanisms include homing to injury sites,anti-inflammatory and immunomodulatory effects,oxidative stress reduction,inhibition of apoptosis and suppression of autophagy.Additionally,MSCs can mitigate multi-organ damage associated with AP,impacting lungs,intestines,heart and other organs.Research on the application of MSCs in treating AP is predominantly at the preclinical animal study stage,with limited clinical investigations reported.This article reviews the mechanisms and research progress of MSCs in the treatment of AP,aiming to provide references for basic research and clinical applications.

关 键 词：间质干细胞 急性病 胰腺炎 重症急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]