内蒙古地区禽蛋、鸡肉中喹诺酮类药物的污染水平及暴露健康风险研究  

Study on quinolone drugs contamination levels and health exposure risk in poultry eggs and chicken meat in Inner Mongolia region

作　　者：陈旭 刘春波 张海燕[2] 包玉兰 张丽敏 赵宏[2] CHEN Xu;LIU Chun-Bo;ZHANG Hai-Yan;BAO Yu-Lan;ZHANG Li-Min;ZHAO Hong(Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine,Hohhot 010010,China;Hohhot Center for Disease Control and Prevention,Hohhot 010010,China)

机构地区：[1]内蒙古自治区中医医院,呼和浩特010010 [2]呼和浩特市疾病预防控制中心,呼和浩特010010

出　　处：《食品安全质量检测学报》2025年第7期63-70,共8页Journal of Food Safety and Quality

基　　金：内蒙古自治区自然科学基金项目(2024FX34)。

摘　　要：目的研究内蒙古地区禽蛋、鸡肉中常见6种喹诺酮类抗生素污染的分布特征及健康风险暴露水平。方法采用同位素内标-固相萃取-超高效液相色谱-串联质谱法测定2021、2022、2024年度对全区部分盟市随机采集的禽蛋和鸡肉样品中诺氟沙星、恩诺沙星、氧氟沙星、培氟沙星、环丙沙星和洛美沙星含量,并对全区禽蛋、鸡肉中喹诺酮类药物残留情况数据进行统计分析,根据不同年龄段人群膳食摄入的参考值和检测的数据,计算各年龄段的危害商,分析其对人群的健康风险。结果2021年禽蛋检出率为5.00%(3/60),暴露量为0.09~0.52μg/(kg·d),危害商为0.004~0.021;鸡肉检出率16.70%(10/60),暴露量为0.23~12.39μg/(kg·d),危害商为0.009~0.492;2022年禽蛋检出率为6.25%(5/80),暴露量为0.09~0.49μg/(kg·d),危害商为0.004~0.019,鸡肉检出率3.75%(3/80),暴露量为0.01~0.68μg/(kg·d),危害商为0.0004~0.0270;2024年禽蛋检出率为3.33%(4/120),暴露量为0.13~0.70μg/(kg·d),危害商为0.005~0.028,鸡肉检出率6.36%(7/110),暴露量为0.03~1.58μg/(kg·d),危害商为0.001~0.063。结论3年的分析数据显示,几乎所有的盟市均在禽蛋或鸡肉中检出喹诺酮抗生素,鸡肉中检出平均值高于禽蛋,4个年龄段人群禽蛋、鸡肉中喹诺酮类抗生素药物暴露风险商均小于1,健康风险较小。Objective To study the distribution characteristics and health risk exposure levels of 6 kinds of common quinolone antibiotics in poultry eggs and chicken meat in Inner Mongolia.Methods The content of norfloxacin,enrofloxacin,ofloxacin,pefloxacin,ciprofloxacin and lomefloxacin in poultry eggs and chicken samples randomly collected from some cities in the region.In 2021,2022 and 2024 were determined by isotope internal standard,solid phase extraction,ultra performance liquid chromatography-tandem mass spectrometry,the data of quinolone residues in poultry eggs and chicken in the whole region were statistically analyzed,according to the reference value of different age groups dietary intake and detected data,the hazard quotient of each age group was calculated and the health risk to the population was analyzed.Results In 2021,the detection rate of poultry eggs was 5.00%(3/60),the exposure levels was 0.09–0.52μg/(kg·d),and the hazard quotient was 0.004–0.021;the detection rate of chicken was 16.70%(10/60),the exposure levels was 0.23–12.39μg/(kg·d),and the hazard quotient was 0.009–0.492.In 2022,the detection rate of poultry eggs was 6.25%(5/80),the exposure levels was 0.09–0.49μg/(kg·d),and the hazard quotient was 0.004–0.019;the detection rate of of chicken was 3.75%(3/80),the exposure levels was 0.01–0.68μg/(kg·d),and the hazard quotient was 0.0004–0.0270.In 2024,the detection rate of poultry eggs was 3.33%(4/120),the exposure levels was 0.13–0.70μg/(kg·d),and the hazard quotient was 0.005–0.028;the detection rate of chicken was 6.36%(7/110),the exposure levels was 0.03–1.58μg/(kg·d),and the hazard quotient was 0.001–0.063.Conclusion The 3 years of analysis data shows that quinolone antibiotics are detected in poultry eggs or chicken almost all cities,the average detected in chicken is higher than that in poultry eggs.The exposure risk of quinolone antibiotics in poultry eggs and chicken in 4 age groups is less than 1 and the health risk is small.

关 键 词：超高效液相色谱-串联质谱法 健康风险 喹诺酮 固相萃取 

分 类 号：F32[经济管理—产业经济]