循环肿瘤细胞与结直肠癌患者不良预后的Meta分析  

Meta Analysis of Circulating Tumor Cells and Adverse Prognosis in Colorectal Cancer Patient

作　　者：贺玲 徐兴东 赵海龙 He Ling;Xu Xingdong;Zhao Hailong(Department of General Practice,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]全科医学科,湖北宜昌443003

出　　处：《巴楚医学》2025年第1期96-103,共8页Bachu Medical Journal

基　　金：湖北省卫生健康委科研项目(WJ2021M067);湖北省知识创新专项项目(2018FB440)。

摘　　要：目的:探究循环肿瘤细胞(CTC)与结直肠癌患者预后的关系。方法:在PubMed、Embase、Web of Science、Medline、中国知网、维普、万方等数据库中检索2007年1月1日—2024年1月1日CTC与结直肠癌患者预后的相关文献,提取数据后采用R语言进行数据分析。结果:本研究纳入14篇文献,共2 378名患者。Meta分析的结果表明,与无循环肿瘤细胞(CTC~-)的患者相比,存在循环肿瘤细胞(CTC~+)的结直肠癌患者总生存期(HR=1.93, 95%CI:1.56, 2.39)及无进展生存期(HR=1.91, 95%CI:1.46,2.50)明显缩短。在CTCs≥3/7.5 mL亚组中,CTC~+患者的总生存期(HR=2.18, 95%CI:1.62,2.93)和无进展生存期(HR=1.75, 95%CI:1.21,2.53)比CTC~-患者更短。结论:CTC是结直肠癌患者预后不良的重要指标,CTC检测可作为评估结直肠癌患者预后的有效措施,为早期识别高危患者并积极采取治疗措施提供重要参考。Objective:To investigate the relationship between circulating tumor cells(CTC)and prognosis in colorectal cancer patients.Methods:Relevant literature on CTC and prognosis of colorectal cancer patients was retrieved from PubMed,Embase,Web of Science,Medline,CNKI,VIP,Wanfang databases,covering the period from January 1,2007 to January 1,2024.After data extraction,R language was used for data analysis.Results:A total of 14 articles involving 2,378 patients were included in this study.The results of the meta-analysis indicated that colorectal cancer patients with circulating tumor cells(CTC+)had significantly shorter overall survival(HR=1.93,95%CI:1.56,2.39)and progression-free survival(HR=1.91,95%CI:1.46,2.50)compared to those without circulating tumor cells(CTC-).In the subgroup with CTCs≥3/7.5 mL,CTC+patients had even shorter overall survival(HR=2.18,95%CI:1.62,2.93)and progression-free survival(HR=1.75,95%CI:1.21,2.53)than CTC-patients.Conclusion:CTC is an important indicator of poor prognosis in colorectal cancer patients.CTC detection can serve as an effective measure for assessing the prognosis of colorectal cancer patients,providing significant reference for early identification of high-risk patients and actively making treatment decisions.

关 键 词：结直肠癌 循环肿瘤细胞 META分析 总生存期 无进展生存期 

分 类 号：R735.37[医药卫生—肿瘤]