芪枣安神汤联合常规治疗对痰热内扰型脑梗死伴失眠患者中医证候积分的影响研究  

Study on the effect of Qizao Anshen decoction combined with conventional treatment on traditional Chinese medicine syndrome score of patients with cerebral infarction and insomnia(interior disturbance of phlegm-heat type)

作　　者：李伟真 LI Wei-zhen(Department of Comprehensive Internal Medicine,Linyi Central Hospital of Traditional Chinese Medicine,Linyi 276400,China)

机构地区：[1]临沂市中心医院中医综合内科,276400

出　　处：《中国现代药物应用》2025年第5期1-6,共6页Chinese Journal of Modern Drug Application

摘　　要：目的分析芪枣安神汤联合常规治疗对痰热内扰型脑梗死伴失眠患者中医证候积分的影响。方法100例痰热内扰型脑梗死伴失眠患者,以随机数字表法分为研究组(采用芪枣安神汤联合常规西药佐匹克隆治疗)和对照组(采用常规西药佐匹克隆治疗),各50例。对比两组疗效、安全性及治疗前后中医证候积分、睡眠质量、神经功能、血清学指标(脑源性神经营养因子、白细胞介素-6、5-羟色胺、神经生长因子)。结果研究组总有效率96.00%明显高于对照组的80.00%(P<0.05)。治疗1、2个疗程后,两组的中医证候积分低于本组治疗前,且研究组的中医证候积分(10.23±1.20)、(5.45±1.24)分明显低于对照组的(14.65±2.31)、(7.28±1.23)分(P<0.05)。治疗1、2个疗程后,两组的匹兹堡睡眠质量指数量表(PSQI)评分低于本组治疗前,且研究组的PSQI评分(10.23±2.14)、(5.05±1.01)分明显低于对照组的(12.23±1.41)、(6.78±1.12)分(P<0.05)。治疗2个疗程后,两组的美国国立卫生研究院卒中量表(NIHSS)评分均低于本组治疗前,且研究组的NIHSS评分(7.13±1.32)分低于对照组的(9.21±2.01)分(P<0.05)。治疗2个疗程后,两组的脑源性神经营养因子、5-羟色胺和神经生长因子高于本组治疗前,白细胞介素-6低于本组治疗前,且研究组的脑源性神经营养因子(48.51±3.23)ng/ml、5-羟色胺(128.51±10.23)ng/ml、神经生长因子(255.81±16.23)ng/L高于对照组的(32.23±2.12)ng/ml、(105.23±6.12)ng/ml、(223.23±14.12)ng/L,白细胞介素-6(9.23±1.12)pg/ml低于对照组的(13.23±2.41)pg/ml(P<0.05)。研究组的不良反应发生率10.00%(5/50)与对照组的8.00%(4/50)对比差异无统计学意义(χ^(2)=0.122,P=0.727>0.05)。结论芪枣安神汤联合常规治疗可提高痰热内扰型脑梗死伴失眠患者的治疗效果,降低中医证候积分,提高睡眠质量,治疗安全性较好。Objective To analyze the effect of Qizao Anshen decoction combined with conventional treatment on traditional Chinese medicine syndrome score of patients with cerebral infarction and insomnia(interior disturbance of phlegm-heat type).Methods A total of 100 patients with cerebral infarction and insomnia(interior disturbance of phlegm-heat type)were divided into study group(Qizao Anshen decoction combined with conventional Western medicine zopiclone treatment)and control group(conventional Western medicine zopiclone treatment)by random numerical table,each with 50 cases.Both groups were compared in terms of efficacy,safety,traditional Chinese medicine syndrome score,sleep quality,neurological function,serological index(brain-derived neurotrophic factor,interleukin-6,5-hydroxytryptamine,nerve growth factor).Results The total effective rate of 96.00%in the study group was significantly higher than 80.00%in the control group(P<0.05).After 1 and 2 courses of treatment,the traditional Chinese medicine syndrome scores in both groups were lower than those before treatment in this group;the traditional Chinese medicine syndrome scores in the study group were(10.23±1.20)and(5.45±1.24)points,which were significantly lower than(14.65±2.31)and(7.28±1.23)points in the control group(P<0.05).After 1 and 2 courses of treatment,the scores of Pittsburgh Sleep Quality Index(PSQI)in both groups were lower than those before treatment in this group;PSQI scores in the study group were(10.23±2.14)and(5.05±1.01)points,which were significantly lower than(12.23±1.41)and(6.78±1.12)points in the control group(P<0.05).After 2 courses of treatment,the National Institutes of Health Stroke Scale(NIHSS)score in both groups was lower than that before treatment in this group,and the study group had a lower NIHSS score of(7.13±1.32)points than(9.21±2.01)points in the control group(P<0.05).After 2 courses of treatment,the levels of brain-derived neurotrophic factor,5-hydroxytryptamine and nerve growth factor in both groups were higher than th

关 键 词：芪枣安神汤 脑梗死 失眠 痰热内扰型 中医证候积分 

分 类 号：R74[医药卫生—神经病学与精神病学]