丁苯酞联合氯吡格雷治疗急性脑梗死患者的效果分析  

Effect analysis of butylphthalide combined with clopidogrel in treating patients with acute cerebral infarction

作　　者：尹梦迪 YIN Meng-di(Department of Medical Equipment,Zibo 148th Hospital,Zibo 255300,China)

机构地区：[1]淄博一四八医院设备科,255300

出　　处：《中国现代药物应用》2025年第5期60-63,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究丁苯酞联合氯吡格雷对急性脑梗死患者的治疗效果。方法选取60例急性脑梗死患者,采用随机数字表法分为研究组(丁苯酞联合氯吡格雷治疗)与对照组(氯吡格雷联合阿司匹林治疗),各30例。比较两组的血流动力学指标、血清指标、不良反应发生率、日常生活能力评分。结果治疗后,两组心率、舒张压、收缩压均较治疗前降低,且研究组心率(73.45±3.18)次/min、舒张压(63.68±2.21)mm Hg(1 mm Hg=0.133 kPa)、收缩压(93.62±4.21)mm Hg均低于对照组的(86.87±3.21)次/min、(73.21±2.19)mm Hg、(113.52±6.34)mm Hg(P<0.05)。治疗后,两组C反应蛋白、血清同型半胱氨酸水平均较治疗前降低,且研究组C反应蛋白(5.32±0.19)mg/L、血清同型半胱氨酸(8.23±0.19)μmol/L均低于对照组的(6.24±0.18)mg/L、(10.09±0.24)μmol/L(P<0.05)。研究组不良反应发生率3.33%低于对照组的20.00%(P<0.05)。治疗后,两组个人卫生自理能力、行走及使用交通工具能力、交流能力、社会认知评分均较治疗前升高,且研究组均高于对照组(P<0.05)。结论丁苯酞联合氯吡格雷治疗急性脑梗死,能够促进患者血流动力学指标、血清指标的恢复,减少不良反应发生情况的发生,促进患者日常生活能力的改善,可予以推广使用。Objective To explore the effect of butylphthalide combined with clopidogrel in treating patients with acute cerebral infarction.Methods 60 patients with acute cerebral infarction were selected and divided into study group(butylphthalide combined with clopidogrel)and control group(clopidogrel combined with aspirin)by random numerical table,with 30 cases in each group.The hemodynamic indexes,serum indexes,incidence of adverse reactions and activity of daily living score were compared between the two groups.Results After treatment,the heart rate,diastolic blood pressure and systolic blood pressure in both groups were lower than those before treatment;in the study group,the heart rate was(73.45±3.18)beats/min,the diastolic blood pressure was(63.68±2.21)mm Hg(1 mm Hg=0.133 kPa),and the systolic blood pressure was(93.62±4.21)mm Hg,which were lower than(86.87±3.21)beats/min,(73.21±2.19)mm Hg,and(113.52±6.34)mm Hg in the control group(P<0.05).After treatment,the levels of C-reactive protein and serum homocysteine in both groups were lower than those before treatment;the C-reactive protein in the study group was(5.32±0.19)mg/L and the serum homocysteine was(8.23±0.19)μmol/L,which were lower than(6.24±0.18)mg/L and(10.09±0.24)μmol/L in the control group(P<0.05).The incidence of adverse reactions(3.33%)in the study group was lower than that in the control group(20.00%)(P<0.05).After treatment,the scores of self-care ability,walking and using transportation ability,communication ability and social cognitive in both groups were higher than those before treatment,and the study group was higher than the control group(P<0.05).Conclusion Butylphthalide combined with clopidogrel in the treatment of acute cerebral infarction can promote the recovery of hemodynamic indexes and serum indexes of patients,reduce the occurrence of adverse reactions,and promote the improvement of patients'activity of daily living,so it can be widely used.

关 键 词：丁苯酞 氯吡格雷 急性脑梗死 血流动力学 日常生活能力 

分 类 号：R74[医药卫生—神经病学与精神病学]