星形胶质细胞调控局灶性癫痫发作动力学与控制  

The Dynamics and Control of Focal Epilepsy Modulated by Astrocytes

作　　者：兰佳宁 王荣 成昕鸿 Lan Jianing;Wang Rong;Cheng Xinhong(College of Science,Xi’an University of Science and Technology,Xi’an 710054,China;College of Mathematics,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]西安科技大学理学院,西安710054 [2]华东理工大学数学学院,上海200237

出　　处：《动力学与控制学报》2025年第1期59-68,共10页Journal of Dynamics and Control

基　　金：国家自然科学基金资助项目(11802229)。

摘　　要：癫痫是一种常见神经系统疾病,其发病机制尚不完全清楚.研究表明,星形胶质细胞在癫痫发作中起到关键作用,可能作为癫痫治疗的靶点.基于临床癫痫脑电特征,建立相匹配的神经元集群-星形胶质细胞集群耦合模型,有助于癫痫发作机制的进一步研究以及癫痫控制技术的发展.本文基于局灶性癫痫发作动力学模型,考虑星形胶质细胞Ca^(2+)波动与神经元集群发放频率的关系,建立神经元集群-星形胶质细胞群耦合动力学模型,探讨了星形胶质细胞群对癫痫发作动力学行为的影响,并模拟刺激治疗,对局灶性癫痫进行抑制.研究发现:星形胶质细胞群与神经元集群的耦合参数驱动模型表现出三种类型的局灶性癫痫发作模式,其共同特点为星形胶质细胞群的谷氨酸过表达;第一种癫痫放电形式可以通过调节星形胶质细胞群与神经元集群耦合参数进行抑制,而其余两种无法通过参数调节进行抑制;常数刺激可以使三种癫痫放电转变为周期放电,但过大或过小的刺激无法完全抑制第一种癫痫放电;高频、强幅值的方波刺激能够有效抑制三种癫痫放电.Epilepsy is a common neurological disorder,but its pathogenesis is not fully understood.Recent studies have shown that astrocytes play a crucial role in epileptic seizures and may serve as a target for epilepsy treatment.Based on the clinical epileptic EEG features,the establishment of a matching neuron-astrocyte population model contributes to further research on seizure mechanisms and the development of epilepsy suppression strategies.In this paper,based on the spontaneous seizure dynamic model of focal epilepsy and considering the relationship between astrocyte Ca 2+fluctuation and neuronal population firing frequency,we established a neuronal-astrocyte populations coupled focal epileptic seizure dynamics model,explored the effect of astrocyte population on seizure dynamics behavior,and simulated stimulation treatment for focal epilepsy.The coupling parameters of the astrocyte to neuron populations can drive the model to exhibit three types of focal seizure patterns,which are commonly characterized by glutamate overexpression of the astrocyte population.The first of these patterns of epileptic discharges can be suppressed by adjusting the coupling parameters between astrocyte and neuron populations,whereas the remaining two cannot be suppressed by parameter adjustments.A constant stimulation can change the three epileptic discharges into periodic discharges,but too large or too small stimulation cannot completely inhibit the first epileptic discharge.The high-frequency and strong-amplitude square-wave stimulation can effectively inhibit the three epileptic discharges.

关 键 词：动力学与控制 局灶性癫痫 星形胶质细胞 神经动力学 

分 类 号：R742.1[医药卫生—神经病学与精神病学]